Surowiecka Agnieszka, Strużyna Jerzy, Winiarska Aleksandra, Korzeniowski Tomasz
East Center of Burns Treatment and Reconstructive Surgery, 21-010 Leczna, Poland.
Department of Plastic Surgery, Reconstructive Surgery and Burn Treatment, Medical University of Lublin, 21-093 Lublin, Poland.
Gels. 2022 Feb 15;8(2):122. doi: 10.3390/gels8020122.
Inert hydrogels are of a great importance in burn first aid. Hydrogel dressings may be an alternative to cooling burn wounds with streaming water, especially in cases of mass casualty events, lack of clean water, hypothermia, or large extent of burns. Hydrogels that contain mostly water evacuate the heat cumulating in the skin by evaporation. They not only cool the burn wound, but also reduce pain and protect the wound area from contamination and further injuries. Hydrogels are ideally used during the first hours after injury, but as they do not have antimicrobial properties , they might not prevent wound infection. The hydrogel matrix enables incorporating active substances into the dressing. The active forms may contain ammonium salts, nanocrystal silver, zinc, growth factor, cytokines, or cells, as well as natural agents, such as honey or herbs. Active dressings may have antimicrobial activity or stimulate wound healing. Numerous experiments on animal models proved their safety and efficiency. Hydrogels are a new dressing type that are still in development.
惰性水凝胶在烧伤急救中具有重要意义。水凝胶敷料可能是用流动水冷却烧伤伤口的一种替代方法，特别是在大规模伤亡事件、缺乏清洁水、体温过低或烧伤面积较大的情况下。主要由水组成的水凝胶通过蒸发排出皮肤中累积的热量。它们不仅能冷却烧伤伤口，还能减轻疼痛并保护伤口区域免受污染和进一步损伤。水凝胶最适合在受伤后的最初几个小时内使用，但由于它们不具有抗菌特性，可能无法预防伤口感染。水凝胶基质能够将活性物质掺入敷料中。活性形式可能包含铵盐、纳米晶银、锌、生长因子、细胞因子或细胞，以及天然物质，如蜂蜜或草药。活性敷料可能具有抗菌活性或刺激伤口愈合。在动物模型上进行的大量实验证明了它们的安全性和有效性。水凝胶是一种仍在开发中的新型敷料。
