Radeva Lyubomira, Kalampalika Eleftheria, Yordanov Yordan, Petrov Petar D, Tzankova Virginia, Yoncheva Krassimira
Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.
Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Gels. 2025 Apr 27;11(5):326. doi: 10.3390/gels11050326.
Caffeine is a well-known xanthine that possesses antioxidant effects that could contribute to its application in different skin disorders. In order to enhance its effects, approaches for improving its permeation and penetration through skin layers could be applied. This study emphasizes the preparation of caffeine-cyclodextrin complex and its formulation in carbopol hydrogel. The complex was developed at a 1:1 molar ratio between caffeine and hydroxypropyl-β-cyclodextrin. It was found that the complex enhanced the radical scavenging activity of caffeine against ABTS radical as well as the protective effects against HO-induced oxidative stress in L929 fibroblasts. Then, the complex was formulated in hydrogel by applying 1% carbopol. The spreadability and penetration of the loaded hydrogel were improved in comparison with the empty hydrogel. The results revealed that the system could be appropriate for therapies of skin disorders, and its wound healing abilities could be further investigated.
咖啡因是一种著名的黄嘌呤，具有抗氧化作用，这可能有助于其在不同皮肤疾病中的应用。为了增强其效果，可以采用改善其透过皮肤层的渗透和穿透的方法。本研究着重于咖啡因 - 环糊精复合物的制备及其在卡波姆水凝胶中的制剂。该复合物是在咖啡因与羟丙基 -β-环糊精以1:1摩尔比的条件下制备的。结果发现，该复合物增强了咖啡因对ABTS自由基的清除活性以及对L929成纤维细胞中过氧化氢诱导的氧化应激的保护作用。然后，通过应用1%的卡波姆将该复合物制成水凝胶。与空白水凝胶相比，负载水凝胶的铺展性和穿透性得到了改善。结果表明，该体系可能适用于皮肤疾病的治疗，其伤口愈合能力可进一步研究。
