Sun Xiaohong, Wang Hao, Li Shengnan, Song Chunli, Zhang Songyuan, Ren Jian, Udenigwe Chibuike C
College of Food and Biological Engineering, Qiqihar University, Qiqihar 161006, China.
Faculty of Health Sciences, School of Nutrition Sciences, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Gels. 2022 Feb 21;8(2):135. doi: 10.3390/gels8020135.
Due to their combination of featured properties, protein and polysaccharide-based carriers show promising potential in food bioactive ingredient encapsulation, protection, and delivery. The formation of protein-polysaccharide complexes and conjugates involves non-covalent interactions and covalent interaction, respectively. The common types of protein-polysaccharide complex/conjugate-based bioactive ingredient delivery systems include emulsion (conventional emulsion, nanoemulsion, multiple emulsion, multilayered emulsion, and Pickering emulsion), microcapsule, hydrogel, and nanoparticle-based delivery systems. This review highlights the applications of protein-polysaccharide-based delivery vehicles in common bioactive ingredients including polyphenols, food proteins, bioactive peptides, carotenoids, vitamins, and minerals. The loaded food bioactive ingredients exhibited enhanced physicochemical stability, bioaccessibility, and sustained release in simulated gastrointestinal digestion. However, limited research has been conducted in determining the in vivo oral bioavailability of encapsulated bioactive compounds. An in vitro simulated gastrointestinal digestion model incorporating gut microbiota and a mucus layer is suggested for future studies.
由于其特性的组合，基于蛋白质和多糖的载体在食品生物活性成分的包封、保护和递送方面显示出有前景的潜力。蛋白质-多糖复合物和缀合物的形成分别涉及非共价相互作用和共价相互作用。基于蛋白质-多糖复合物/缀合物的生物活性成分递送系统的常见类型包括乳液（常规乳液、纳米乳液、多重乳液、多层乳液和皮克林乳液）、微胶囊、水凝胶和基于纳米颗粒的递送系统。本综述重点介绍了基于蛋白质-多糖的递送载体在常见生物活性成分中的应用，包括多酚、食品蛋白质、生物活性肽、类胡萝卜素、维生素和矿物质。负载的食品生物活性成分在模拟胃肠消化中表现出增强的物理化学稳定性、生物可及性和缓释性。然而，在确定包封生物活性化合物的体内口服生物利用度方面的研究有限。建议未来的研究采用包含肠道微生物群和黏液层的体外模拟胃肠消化模型。
