Agricultural Bio-Pharmaceutical Laboratory, Qingdao Agricultural University, Qingdao 266109, China.
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Mar Drugs. 2022 Jan 24;20(2):95. doi: 10.3390/md20020095.
The design and development of innovative multifunctional wound dressing materials in engineered biomaterials is essential for promoting tissue repair. In this study, nanofibrous wound dressing materials loaded with anti-inflammatory ingredients were manufactured by a promising electrospinning strategy, and their capability for treating diabetic wounds was also investigated. A scaffold blend consisting of an Enteromorpha polysaccharide and polyvinyl alcohol (PVA) was fabricated. The in vitro and in vivo studies confirmed the efficacy of PVA/EPP1 fiber. We found that PVA/EPP1 fiber accelerated the repair of a full-thickness skin wound in diabetic mice. The results suggest that this scaffold could effectively shorten the wound healing time by inhibiting inflammatory activity, which makes it a promising candidate for the treatment of hard-to-heal wounds caused by diabetes.
在工程生物材料中设计和开发创新的多功能伤口敷料材料对于促进组织修复至关重要。在这项研究中，通过一种有前途的静电纺丝策略制造了负载抗炎成分的纳米纤维伤口敷料材料，并研究了它们治疗糖尿病伤口的能力。制备了由浒苔多糖和聚乙烯醇（PVA）组成的支架混合物。体外和体内研究证实了 PVA/EPP1 纤维的功效。我们发现 PVA/EPP1 纤维可加速糖尿病小鼠全层皮肤伤口的修复。结果表明，该支架通过抑制炎症活性可有效缩短伤口愈合时间，使其成为治疗糖尿病引起的难治性伤口的有前途的候选材料。
