College of Materials Science and Engineering, Wuhan Textile University, Wuhan 430073, People's Republic of China.
School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, People's Republic of China.
Int J Biol Macromol. 2020 Jul 15;155:903-910. doi: 10.1016/j.ijbiomac.2019.11.048. Epub 2019 Nov 13.
Although electrospinning of nanofibrous scaffolds benefit to wound healing have been developed at a fast pace, achieving nanofibrous scaffolds with high absorptivity by green electrospinning and crosslinking techniques is still a great challenge. Here, we developed a maleilated hyaluronate/methacrylated poly (vinyl alcohol) (MHA) (MaPVA) composite nanofibers by electrospinning from pure water solvent and followed by photopolymerization to form crosslinking nanofibers network. Electrospinnability of MHA/MaPVA blend systems were investigated and the results shows that the morphology and diameter of the nanofibers were mainly affected by MHA/MaPVA weight ratios by changing viscosity and conductivity of the blend solutions. The crystalline microstructure of the electrospun fibers was not well developed due to intermolecular hydrogen bonding interaction between the molecules of MHA and MaPVA. The photocrosslinking MHA/MaPVA nanofibrous mats can swell to form fibrous hydrogels with high water absorption, meanwhile it is cytocompatible and capable of promoting the cell attachment, which render it great potential for wound dressings.
尽管基于静电纺丝技术的纳米纤维支架在伤口愈合方面已经得到了快速发展，但通过绿色静电纺丝和交联技术实现高吸水性的纳米纤维支架仍然是一个巨大的挑战。在这里，我们通过纯水溶液静电纺丝制备了马来酸酐化透明质酸钠/甲基丙烯酰化聚（乙烯醇）（MHA）（MaPVA）复合纳米纤维，并通过光聚合形成交联纳米纤维网络。研究了 MHA/MaPVA 共混体系的可纺性，结果表明，通过改变共混溶液的粘度和电导率，MHA/MaPVA 重量比主要影响纳米纤维的形态和直径。由于 MHA 和 MaPVA 分子之间的分子间氢键相互作用，电纺纤维的结晶微结构发育不良。光交联的 MHA/MaPVA 纳米纤维垫可以溶胀形成具有高吸水性的纤维状水凝胶，同时具有细胞相容性和促进细胞附着的能力，这使其在伤口敷料方面具有很大的潜力。
