海洋生物中分离的 Gorgostane 型甾体的化学综述及其 C-NMR 光谱数据特征。

Chemical Review of Gorgostane-Type Steroids Isolated from Marine Organisms and Their C-NMR Spectroscopic Data Characteristics.

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.

Department of Pharmacognosy, Faculty of Pharmacy, South Valley University, Qena 83523, Egypt.

出版信息

Mar Drugs. 2022 Feb 14;20(2):139. doi: 10.3390/md20020139.

DOI:10.3390/md20020139

PMID:35200668

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8878145/

Abstract

Gorgostane steroids are isolated from marine organisms and consist of 30 carbon atoms with a characteristic cyclopropane moiety. From the pioneering results to the end of 2021, isolation, biosynthesis, and structural elucidation using C-NMR will be used. Overall, 75 compounds are categorized into five major groups: gorgost-5-ene, 5,6-epoxygorgostane, 5,6-dihydroxygorgostane, 9,11-secogorgostane, and 23-demethylgorgostane, in addition to miscellaneous gorgostane. The structural diversity, selectivity for marine organisms, and biological effects of gorgostane steroids have generated considerable interest in the field of drug discovery research.

摘要

高根甾醇甾体化合物从海洋生物中分离得到，由 30 个碳原子组成，具有特征性的环丙烷部分。从开创性的结果到 2021 年底，将使用 C-NMR 进行分离、生物合成和结构阐明。总体上，75 种化合物分为五个主要类别：高根-5-烯、5,6-环氧高根甾烷、5,6-二羟基高根甾烷、9,11-次高根甾烷和 23-去甲高根甾烷，以及各种高根甾烷。高根甾醇甾体化合物的结构多样性、对海洋生物的选择性和生物效应引起了药物发现研究领域的极大兴趣。