Far Eastern Geological Institute, Russian Academy of Sciences, 159 Prospect 100-letiya Vladivostoka, 690022 Vladivostok, Russia.
Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121 Moscow, Russia.
Mar Drugs. 2021 Apr 24;19(5):240. doi: 10.3390/md19050240.
The review focuses on sulfated steroids that have been isolated from seaweeds, marine sponges, soft corals, ascidians, starfish, and other marine invertebrates. Sulfur-containing steroids and triterpenoids are sourced from sedentary marine coelenterates, plants, marine sediments, crude oil, and other geological deposits. The review presents the pharmacological profile of sulfated steroids, sulfur-containing steroids, and triterpenoids, which is based on data obtained using the PASS program. In addition, several semi-synthetic and synthetic epithio steroids, which represent a rare group of bioactive lipids that have not yet been found in nature, but possess a high level of antitumor activity, were included in this review for the comparative pharmacological characterization of this class of compounds. About 140 steroids and triterpenoids are presented in this review, which demonstrate a wide range of biological activities. Therefore, out of 71 sulfated steroids, thirteen show strong antitumor activity with a confidence level of more than 90%, out of 50 sulfur-containing steroids, only four show strong antitumor activity with a confidence level of more than 93%, and out of eighteen epithio steroids, thirteen steroids show strong antitumor activity with a confidence level of 91% to 97.4%.
本文综述了从海藻、海洋海绵、软珊瑚、海鞘、海星和其他海洋无脊椎动物中分离得到的硫酸甾体。含硫甾体和三萜类化合物来源于固着海洋腔肠动物、植物、海洋沉积物、原油和其他地质沉积物。本文根据 PASS 程序获得的数据，介绍了硫酸甾体、含硫甾体和三萜类化合物的药理学特性。此外，本文还纳入了几种半合成和合成的表硫甾体，它们代表了一类尚未在自然界中发现的具有高抗肿瘤活性的稀有生物活性脂质，用于这一类化合物的比较药理学特征描述。本文共介绍了约 140 种甾体和三萜类化合物，它们表现出广泛的生物活性。因此，在 71 种硫酸甾体中，有 13 种具有超过 90%置信水平的强抗肿瘤活性，在 50 种含硫甾体中，只有 4 种具有超过 93%置信水平的强抗肿瘤活性，在 18 种表硫甾体中，有 13 种甾体具有 91%至 97.4%置信水平的强抗肿瘤活性。
