来自越南软珊瑚细枝软柳珊瑚的细胞毒性甾体化合物。
Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia leptoclados.
作者信息
Ngoc Ninh Thi, Hanh Tran Thi Hong, Thanh Nguyen Van, Thao Do Thi, Cuong Nguyen Xuan, Nam Nguyen Hoai, Thung Do Cong, Kiem Phan Van, Minh Chau Van
机构信息
Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).
Graduate University of Science and Technology, VAST.
出版信息
Chem Pharm Bull (Tokyo). 2017 Jun 1;65(6):593-597. doi: 10.1248/cpb.c17-00129. Epub 2017 Mar 18.
Fifteen steroids, including two new compounds, leptosteroid (1) and 5,6β-epoxygorgosterol (2), were isolated and structurally elucidated from the Vietnamese soft coral Sinularia leptoclados. Their cytotoxic effect against a panel of eight human cancer cell lines was evaluated using sulforhodamine B (SRB) method. Significant cytotoxicity against hepatoma cancer (HepG2, IC=21.13±0.70 µM) and colon adenocarcinoma (SW480, IC=28.65±1.53 µM) cell lines were observed for 1 and against acute leukemia (HL-60, IC=20.53±2.26 µM) and SW480 (IC=26.61±1.59 µM) for ergost-5-en-3β,7β-diol (8). In addition, 3β,7β-dihydroxyergosta-5,24(28)-diene (13) showed significant cytotoxic activity on all tested cell lines with IC values ranging from 13.45±1.81 to 29.01±3.21 µM.
从越南软珊瑚细枝软珊瑚中分离并鉴定了15种甾体化合物，其中包括两种新化合物，细枝甾体（1）和5,6β-环氧麦角甾醇（2）。使用磺酰罗丹明B（SRB）法评估了它们对一组8种人类癌细胞系的细胞毒性作用。化合物1对肝癌细胞（HepG2，IC = 21.13±0.70 μM）和结肠腺癌细胞（SW480，IC = 28.65±1.53 μM）具有显著的细胞毒性，麦角甾-5-烯-3β,7β-二醇（8）对急性白血病细胞（HL-60，IC = 20.53±2.26 μM）和SW480细胞（IC = 26.61±1.59 μM）具有显著的细胞毒性。此外，3β,7β-二羟基麦角甾-5,24(28)-二烯（13）对所有测试细胞系均表现出显著的细胞毒性活性，IC值范围为13.45±1.81至29.01±3.21 μM。
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