Appl Opt. 2021 Dec 10;60(35):10855-10861. doi: 10.1364/AO.439250.
Multiwavelength photo-magnetic imaging (PMI) is a novel combination of diffuse optics and magnetic resonance imaging, to the best of our knowledge, that yields tissue chromophore concentration maps with high resolution and quantitative accuracy. Here, we present the first experimental results, to the best of our knowledge, obtained using a spectrally constrained PMI image reconstruction method, where chromophore concentration maps are directly recovered, unlike the conventional two-step approach that requires an intermediate step of reconstructing wavelength-dependent absorption coefficient maps. The imposition of the prior spectral information into the PMI inverse problem improves the reconstructed image quality and allows recovery of highly quantitative concentration maps, which are crucial for effective cancer detection and characterization. The obtained results demonstrate the higher performance of the direct reconstruction method. Indeed, the reconstructed concentration maps are not only of higher quality but also obtained approximately 2 times faster than the conventional method.
多波长光磁共振成像（PMI）是漫射光学和磁共振成像的一种新组合，据我们所知，它可以以高分辨率和定量精度获得组织色素浓度图。在这里，我们提出了第一个实验结果，据我们所知，该结果是使用光谱约束的 PMI 图像重建方法获得的，与传统的两步法不同，该方法需要中间步骤来重建波长相关的吸收系数图。将先验光谱信息施加到 PMI 反问题中可以提高重建图像的质量，并允许恢复高度定量的浓度图，这对于有效检测和表征癌症至关重要。所得到的结果表明了直接重建方法的更高性能。实际上，重建的浓度图不仅质量更高，而且比传统方法快约 2 倍。
