Research and Development Wing, Sree Balaji Medical College and Hospital (SBMCH), Bharath Institute of Higher Education and Research (BIHER), Chennai, Tamil Nadu, India.
Department of Chemical Engineering, Ming Chi University of Technology, Taishan, Taipei, Taiwan.
Crit Rev Anal Chem. 2023;53(8):1828-1839. doi: 10.1080/10408347.2022.2043145. Epub 2022 Feb 24.
Biomarkers are biological molecules associated with physiological changes of the body and aids in the detecting the onset of disease in patients. There is an urgent need for self-monitoring and early detection of cardiovascular and other health complications. Several blood-based biomarkers have been well established in diagnosis and monitoring the onset of diseases. However, the detection level of biomarkers in bed-side analysis is difficult and complications arise due to the endothelial dysfunction. Currently single volatile organic compounds (VOCs) based sensors are available for the detection of human diseases and no dedicated nanosensor is available for the elderly. Moreover, accuracy of the sensors based on a single analyte is limited. Hence, breath analysis has received enormous attention in healthcare due to its relatively inexpensive, rapid, and noninvasive methods for detecting diseases. This review gives a detailed analysis of how biomarker imprinted nanosensor can be used as a noninvasive method for detecting VOC to health issues early using exhaled breath analysis.
生物标志物是与身体生理变化相关的生物分子，有助于检测患者疾病的发生。迫切需要对心血管和其他健康并发症进行自我监测和早期检测。有几种基于血液的生物标志物已被很好地确立，用于诊断和监测疾病的发生。然而，床边分析中生物标志物的检测水平很困难，并且由于内皮功能障碍会出现并发症。目前，已经有基于单一挥发性有机化合物 (VOC) 的传感器可用于检测人类疾病，但没有专门用于老年人的纳米传感器。此外，基于单一分析物的传感器的准确性有限。因此，由于其具有相对廉价、快速和非侵入性的疾病检测方法，呼吸分析在医疗保健领域受到了极大的关注。本综述详细分析了如何使用生物标志物印迹纳米传感器作为一种非侵入性方法，通过呼气分析早期检测与健康问题相关的挥发性有机化合物。
