Zuo Wen, Chen Ting, Song Jiayi, Ai Ming
Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Ocul Immunol Inflamm. 2023 Apr;31(3):491-495. doi: 10.1080/09273948.2022.2032199. Epub 2022 Feb 24.
To assess the predictive value of inflammatory markers calculated from complete blood counts in patients with retinal vein occlusion (RVO).
This was a retrospective cross-sectional study with a total of 56 RVO patients and 56 age- and gender-matched controls involved. All subjects went through a routine ocular examination, and the peripheral venous blood samples were collected to analyze the differences in inflammatory markers between groups.
The systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) values were significantly higher in RVO patients than those in the controls (p=0.002, p=0.004, respectively). According to the receiver operating characteristic (ROC) curve analysis, the areas under the curve (AUC) of SII was 0.666. The AUC of NLR was 0.657.
As a novel inflammatory indicator, SII is a more promising indicator than NLR and PLR in the prediction of RVO development.
评估通过全血细胞计数计算得出的炎症标志物对视网膜静脉阻塞（RVO）患者的预测价值。
这是一项回顾性横断面研究，共纳入56例RVO患者和56例年龄及性别匹配的对照者。所有受试者均接受常规眼科检查，并采集外周静脉血样本以分析组间炎症标志物的差异。
RVO患者的全身免疫炎症指数（SII）和中性粒细胞与淋巴细胞比值（NLR）值显著高于对照组（分别为p = 0.002，p = 0.004）。根据受试者工作特征（ROC）曲线分析，SII的曲线下面积（AUC）为0.666。NLR的AUC为0.657。
作为一种新型炎症指标，SII在预测RVO发展方面比NLR和血小板与淋巴细胞比值（PLR）更具前景。
