Department of Ophthalmology, Trakya University School of Medicine, Edirne, Turkey.
Nagoya J Med Sci. 2023 May;85(2):289-298. doi: 10.18999/nagjms.85.2.289.
This study aims to determine the relationship between systemic inflammatory biomarkers and primary acquired nasolacrimal duct obstruction and to evaluate whether they can be used as indicators in determining the risk of recurrence after dacryocystorhinostomy. This retrospective, comparative case series was conducted with 57 primary acquired nasolacrimal duct obstruction patients and 58 age- and gender-matched controls. All subjects underwent a complete ophthalmologic examination and complete blood count measurements. The mean neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammation index were significantly higher in patients with primary acquired nasolacrimal duct obstruction (p = 0.005, p = 0.01, and p = 0.003, respectively). In recurrent patients, the neutrophil-to-lymphocyte ratio was significantly higher than in those who did not develop a recurrence (p = 0.029). The area under the curve was determined as 0.775 (p = 0.029) for the neutrophil-to-lymphocyte ratio in predicting recurrence. The neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammation index levels were significantly higher in patients with primary acquired nasolacrimal duct obstruction compared to healthy controls. The neutrophil-to-lymphocyte ratio might be used as a simple and inexpensive indicator for predicting recurrence in patients with primary acquired nasolacrimal duct obstruction.
本研究旨在探讨系统性炎症生物标志物与原发性获得性鼻泪管阻塞的关系，并评估其是否可作为鼻泪囊造口术后复发风险的预测指标。这是一项回顾性、对照病例系列研究，纳入了 57 例原发性获得性鼻泪管阻塞患者和 58 例年龄和性别匹配的对照组。所有受试者均接受了全面的眼科检查和全血细胞计数测量。原发性获得性鼻泪管阻塞患者的中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值和全身免疫炎症指数均显著升高（p=0.005、p=0.01 和 p=0.003）。在复发性患者中，中性粒细胞与淋巴细胞比值显著高于未复发患者（p=0.029）。中性粒细胞与淋巴细胞比值预测复发的曲线下面积为 0.775（p=0.029）。与健康对照组相比，原发性获得性鼻泪管阻塞患者的中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值和全身免疫炎症指数水平显著升高。中性粒细胞与淋巴细胞比值可能可作为预测原发性获得性鼻泪管阻塞患者复发的简单、经济的指标。
