Nursing Department, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Ophthalmology, The Second People's Hospital of Jinan, Jinan, China.
Ophthalmic Res. 2023;66(1):1096-1103. doi: 10.1159/000531824. Epub 2023 Jul 10.
The aim of this study was to investigate the characteristics of hematologic parameters in young patients with retinal vein occlusion (RVO).
All participants underwent routine ocular examinations and blood sample tests. Hematologic parameters obtained from a complete blood count, as well as the calculation of specific inflammatory indices, were compared between young patients with RVO and the control subjects. Correlations between hematologic inflammatory biomarkers and aqueous humor inflammatory cytokines were also investigated.
A total of 64 patients with RVO and 64 age- and gender-matched control subjects were included in this study. The white blood cell count, neutrophil cell count, mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) in young patients with RVO were significantly higher than in the controls (all p < 0.05). Compared to patients with nonischemic RVO, patients with ischemic RVO had higher NLR, SII, and SIRI values (p = 0.032, p = 0.035, and p = 0.039, respectively). The areas under the receiver operator characteristic curve were 0.725, 0.651, 0.649, and 0.634 for the MPV, NLR, SII, and SIRI, respectively. In addition, a higher NLR was related to higher levels of interleukin 6 (IL-6; p = 0.046, R = 0.463), and a higher SII was related to higher levels of IL-6 (p = 0.034, R = 0.488) and vascular endothelial growth factor (p = 0.020, R = 0.528).
The NLR, SII, and SIRI were significantly elevated in young patients with RVO, especially in young patients with ischemic RVO. NLR and SII were positively correlated with IL-6 levels in aqueous humor, which indicated that systemic inflammation plays an important role in the onset of RVO in young patients.
本研究旨在探讨年轻视网膜静脉阻塞（RVO）患者血液学参数的特征。
所有参与者均接受常规眼部检查和血液样本检测。比较年轻 RVO 患者和对照组的全血细胞计数获得的血液学参数，以及特定炎症指数的计算结果。还研究了血液学炎症生物标志物与房水炎症细胞因子之间的相关性。
本研究共纳入 64 例 RVO 患者和 64 例年龄和性别匹配的对照组。年轻 RVO 患者的白细胞计数、中性粒细胞计数、平均血小板体积（MPV）、中性粒细胞与淋巴细胞比值（NLR）、全身性免疫炎症指数（SII）和全身性炎症反应指数（SIRI）均显著高于对照组（均 P < 0.05）。与非缺血性 RVO 患者相比，缺血性 RVO 患者的 NLR、SII 和 SIRI 值更高（p = 0.032、p = 0.035 和 p = 0.039）。MPV、NLR、SII 和 SIRI 的受试者工作特征曲线下面积分别为 0.725、0.651、0.649 和 0.634。此外，较高的 NLR 与白细胞介素 6（IL-6）水平升高相关（p = 0.046，R = 0.463），较高的 SII 与 IL-6（p = 0.034，R = 0.488）和血管内皮生长因子（p = 0.020，R = 0.528）水平升高相关。
年轻 RVO 患者的 NLR、SII 和 SIRI 显著升高，尤其是年轻缺血性 RVO 患者。NLR 和 SII 与房水中的 IL-6 水平呈正相关，表明全身炎症在年轻 RVO 患者的发病中起重要作用。
