Mazurov Evgeny, Sizykh Alexey, Medvedeva Yulia A
Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Sciences, 117312 Moscow, Russia.
School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny, 141701 Moscow, Russia.
Noncoding RNA. 2022 Feb 8;8(1):18. doi: 10.3390/ncrna8010018.
Long non-coding RNAs (lncRNAs) play an important role in genome regulation. Specifically, many lncRNAs interact with chromatin, recruit epigenetic complexes and in this way affect large-scale gene expression programs. However, the experimental data about lncRNA-chromatin interactions is still limited. The majority of experimental protocols do not provide any insight into the mechanics of lncRNA-based genome-wide epigenetic regulation. Here we present the HiMoRNA (Histone-Modifying RNA) database, a resource containing correlated lncRNA-epigenetic changes in specific genomic locations genome-wide. HiMoRNA integrates a large amount of multi-omics data to characterize the effects of lncRNA on epigenetic modifications and gene expression. The current release of HiMoRNA includes more than five million associations in humans for ten histone modifications in multiple genomic loci and 4145 lncRNAs. HiMoRNA provides a user-friendly interface to facilitate browsing, searching and retrieving of lncRNAs associated with epigenetic profiles of various chromatin loci. Analysis of the HiMoRNA data suggests that several lncRNA including JPX might be involved not only in regulation of XIST locus but also in direct establishment or maintenance of X-chromosome inactivation. We believe that HiMoRNA is a convenient and valuable resource that can provide valuable biological insights and greatly facilitate functional annotation of lncRNAs.
长链非编码RNA（lncRNAs）在基因组调控中发挥着重要作用。具体而言，许多lncRNAs与染色质相互作用，招募表观遗传复合物，从而影响大规模基因表达程序。然而，关于lncRNA-染色质相互作用的实验数据仍然有限。大多数实验方案并未提供任何关于基于lncRNA的全基因组表观遗传调控机制的见解。在此，我们展示了HiMoRNA（组蛋白修饰RNA）数据库，这是一个包含全基因组特定基因组位置上相关lncRNA-表观遗传变化的资源库。HiMoRNA整合了大量多组学数据，以表征lncRNA对表观遗传修饰和基因表达的影响。HiMoRNA的当前版本包含了人类多个基因组位点中针对十种组蛋白修饰的超过五百万个关联信息以及4145个lncRNAs。HiMoRNA提供了一个用户友好的界面，便于浏览、搜索和检索与各种染色质位点表观遗传图谱相关的lncRNAs。对HiMoRNA数据的分析表明，包括JPX在内的几种lncRNA可能不仅参与XIST位点的调控，还参与X染色体失活的直接建立或维持。我们相信，HiMoRNA是一个方便且有价值的资源库，能够提供有价值的生物学见解，并极大地促进lncRNAs的功能注释。
