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Toxics. 2021 Nov 11;9(11):299. doi: 10.3390/toxics9110299.
2
DNA oxidative damage in pregnant women upon exposure to conventional and alternative phthalates.孕妇接触传统和替代邻苯二甲酸酯后的 DNA 氧化损伤。
Environ Int. 2021 Nov;156:106743. doi: 10.1016/j.envint.2021.106743. Epub 2021 Jul 6.
3
Relationship of Urinary Phthalate Metabolites with Cardiometabolic Risk Factors and Oxidative Stress Markers in Children and Adolescents.儿童和青少年尿邻苯二甲酸代谢物与心血管代谢危险因素和氧化应激标志物的关系。
J Environ Public Health. 2021 Apr 27;2021:5514073. doi: 10.1155/2021/5514073. eCollection 2021.
4
Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico.波多黎各孕妇体内邻苯二甲酸代谢物对氧化应激生物标志物的个体和联合效应。
Environ Int. 2021 Sep;154:106565. doi: 10.1016/j.envint.2021.106565. Epub 2021 Apr 23.
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Effects and Mechanisms of Phthalates' Action on Reproductive Processes and Reproductive Health: A Literature Review.邻苯二甲酸酯类对生殖过程和生殖健康的作用及机制：文献综述。
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Urinary phthalate metabolites are associated with biomarkers of DNA damage and lipid peroxidation in pregnant women - Tainan Birth Cohort Study (TBCS).孕妇尿液邻苯二甲酸代谢物与 DNA 损伤和脂质过氧化生物标志物的相关性——台南出生队列研究（TBCS）。
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Phthalate metabolites and biomarkers of oxidative stress in the follicular fluid of women undergoing in vitro fertilization.在体外受精的女性卵泡液中邻苯二甲酸代谢物和氧化应激生物标志物。
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Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center.在生育中心就诊的男性中双酚 A 和邻苯二甲酸酯暴露与精液参数的横断面研究。
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邻苯二甲酸酯暴露与核酸氧化生物标志物：对前往生育中心的夫妇的研究结果

Phthalate Exposure and Biomarkers of Oxidation of Nucleic Acids: Results on Couples Attending a Fertility Center.

作者信息

Pigini Daniela, Caporossi Lidia, Paci Enrico, Capanna Silvia, Viganò Paola, Alteri Alessandra, Rabellotti Elisa, Buonaurio Flavia, Papaleo Bruno, Tranfo Giovanna

机构信息

INAIL, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Via Fontana Candida 1, 00078 Monte Porzio Catone, Italy.

Obstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy.

出版信息

Toxics. 2022 Jan 29;10(2):61. doi: 10.3390/toxics10020061.

DOI:10.3390/toxics10020061
PMID:35202248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8876283/
Abstract

Phthalates are substances used as plasticizing agents and solvents that can increase the risk of infertility and that appear to induce oxidative stress. The aim of the study was to show the possible relationship between urinary concentrations of phthalates metabolites, namely MEP, MBzP, MnBP, MEHP, MEHHP, and MnOP and biomarkers of nucleic acids oxidation, methylation, or protein nitroxidation. The oxidative stress biomarkers measured in human urine were 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, 8-oxo-7,8-dihydro-2'-deoxyguanosine, 3-nitrotyrosine, and 5-methylcytidine. Two hundred and seventy-four couples were enrolled, undergoing an assisted reproduction technology (ART) treatment, urine samples were analyzed in HPLC/MS-MS, and then two sub-groups with urinary concentration > 90th or <10th percentile were identified, reducing the sample size to 112 subjects. The levels of oxidative stress biomarkers were measured in both groups, reduced to 52 men and 60 women. A statistically significantly difference for 8-oxoGuo and 3-NOTyr between men and women, with higher levels in men, was found. The levels of oxidative stress biomarkers were directly correlated with some phthalate concentrations in both sexes.

摘要

邻苯二甲酸盐是用作增塑剂和溶剂的物质，会增加不孕风险，且似乎会引发氧化应激。本研究的目的是揭示邻苯二甲酸盐代谢物（即MEP、MBzP、MnBP、MEHP、MEHHP和MnOP）的尿液浓度与核酸氧化、甲基化或蛋白质氮氧化的生物标志物之间可能存在的关系。在人类尿液中测量的氧化应激生物标志物包括8-氧代-7,8-二氢鸟嘌呤、8-氧代-7,8-二氢鸟苷、8-氧代-7,8-二氢-2'-脱氧鸟苷、3-硝基酪氨酸和5-甲基胞苷。招募了274对接受辅助生殖技术（ART）治疗的夫妇，对尿液样本进行HPLC/MS-MS分析，然后确定尿液浓度高于第90百分位数或低于第10百分位数的两个亚组，将样本量减少至112名受试者。在两组中测量氧化应激生物标志物的水平，并将样本量减少至52名男性和60名女性。发现男性和女性之间8-氧代鸟嘌呤（8-oxoGuo）和3-硝基酪氨酸（3-NOTyr）存在统计学显著差异，男性水平更高。氧化应激生物标志物水平在两性中均与某些邻苯二甲酸盐浓度直接相关。