Drevet Joël R, Aitken Robert John
Faculty of Medicine, GReD Institute, INSERM U1103-CNRS UMR6293-Université Clermont Auvergne, CRBC building, 28 place Henri Dunant, 63001 Clermont-Ferrand, France.
School of Environmental and Life Sciences, Priority Research Centre for Reproductive Sciences, The University of Newcastle, Callaghan, Newcastle 2308, Australia.
Antioxidants (Basel). 2020 Jan 23;9(2):95. doi: 10.3390/antiox9020095.
Sperm cells have long been known to be good producers of reactive oxygen species, while they are also known to be particularly sensitive to oxidative damage affecting their structures and functions. As with all organic cellular components, sperm nuclear components and, in particular, nucleic acids undergo oxidative alterations that have recently been shown to be commonly encountered in clinical practice. This review will attempt to provide an overview of this situation. After a brief coverage of the biological reasons why the sperm nucleus and associated DNA are sensitive to oxidative damage, a summary of the most recent results concerning the oxidation of sperm DNA in animal and human models will be presented. The study will then attempt to cover the possible consequences of sperm nuclear oxidation on male fertility and beyond.
长期以来，人们一直知道精子细胞是活性氧的良好产生者，同时也知道它们对影响其结构和功能的氧化损伤特别敏感。与所有有机细胞成分一样，精子核成分，尤其是核酸会发生氧化改变，最近的研究表明，这种情况在临床实践中很常见。本综述将试图对此情况进行概述。在简要介绍精子核及相关DNA对氧化损伤敏感的生物学原因之后，将总结动物和人类模型中精子DNA氧化的最新研究结果。然后，该研究将试图涵盖精子核氧化对男性生育及其他方面可能产生的后果。
