Califano A, Poli T, Vannini G L
Mycopathologia. 1986 Mar;93(3):189-92. doi: 10.1007/BF00443523.
A new pyrazolo [3, 4-d]pyrimidine derivative was synthesized and its antifungal activity evaluated in vitro against mycelial and yeast cells of Candida albicans. The most striking ultrastructural changes following treatment with 10-30 micrograms/ml (mycelia) and 25-75 micrograms/ml (yeasts) consisted in the deterioration of the organelle membranes and in aberrant thickenings of the cell wall. The complete disorganization of the cytoplasmic structures seemed to be the final event.
合成了一种新的吡唑并[3,4 - d]嘧啶衍生物，并对其抗白色念珠菌菌丝体和酵母细胞的体外抗真菌活性进行了评估。用10 - 30微克/毫升（菌丝体）和25 - 75微克/毫升（酵母）处理后，最显著的超微结构变化包括细胞器膜的退化和细胞壁异常增厚。细胞质结构的完全紊乱似乎是最终结果。
