College of Veterinary Medicine, South China Agricultural University, No. 483 Wushan Road, Tianhe District, Guangzhou 510642, China.
Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
Cells. 2022 Feb 17;11(4):711. doi: 10.3390/cells11040711.
Mitophagy, which is able to selectively clear excess or damaged mitochondria, plays a vital role in the quality control of mitochondria and the maintenance of normal mitochondrial functions in eukaryotic cells. Mitophagy is involved in many physiological and pathological processes, including apoptosis, innate immunity, inflammation, cell differentiation, signal transduction, and metabolism. Viral infections cause physical dysfunction and thus pose a significant threat to public health. An accumulating body of evidence reveals that some viruses hijack mitophagy to enable immune escape and self-replication. In this review, we systematically summarize the pathway of mitophagy initiation and discuss the functions and mechanisms of mitophagy in infection with classical swine fever virus and other specific viruses, with the aim of providing a theoretical basis for the prevention and control of related diseases.
自噬，能够选择性地清除多余或受损的线粒体，在真核细胞中线粒体的质量控制和维持正常线粒体功能方面发挥着至关重要的作用。自噬参与许多生理和病理过程，包括细胞凋亡、先天免疫、炎症、细胞分化、信号转导和代谢。病毒感染会导致身体功能障碍，因此对公共健康构成重大威胁。越来越多的证据表明，一些病毒劫持自噬来实现免疫逃避和自我复制。在这篇综述中，我们系统地总结了自噬起始的途径，并讨论了自噬在经典猪瘟病毒感染和其他特定病毒感染中的功能和机制，旨在为相关疾病的预防和控制提供理论依据。
