乙型肝炎病毒蛋白 HBx 及其调控肝细胞癌特征的分子机制：全面综述。
Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review.
机构信息
Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.
Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L69 7BE, UK.
出版信息
Cells. 2022 Feb 21;11(4):741. doi: 10.3390/cells11040741.
With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key multifunctional regulatory protein, drives viral replication and interferes with several cellular signalling pathways that drive virus-associated hepatocarcinogenesis. This review article provides a comprehensive overview of the role of HBx in modulating the various hallmarks of HCC by supporting tumour initiation, progression, invasion and metastasis. Understanding HBx-mediated dimensions of complexity in driving liver malignancies could provide the key to unlocking novel and repurposed combinatorial therapies to combat HCC.
据估计，全世界有 2.96 亿例慢性乙型肝炎病毒（HBV）感染，是肝细胞癌（HCC）最常见的危险因素。HBV 编码的癌基因 X 蛋白（HBx）是一种关键的多功能调节蛋白，它驱动病毒复制，并干扰几种细胞信号通路，从而促进与病毒相关的肝癌发生。这篇综述文章全面概述了 HBx 通过支持肿瘤起始、进展、侵袭和转移，来调节 HCC 的各种特征的作用。了解 HBx 在驱动肝恶性肿瘤方面的复杂性，可以为开发新的和重新利用的组合疗法来治疗 HCC 提供关键。
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