Axelerad Any Docu, Muja Lavinia Florenta, Stroe Alina Zorina, Zlotea Lavinia Alexandra, Sirbu Carmen Adella, Docu Axelerad Silviu, Jianu Dragos Catalin, Frecus Corina Elena, Mihai Cristina Maria
Department of Neurology, General Medicine Faculty, Ovidius University, 900470 Constanta, Romania.
Radiology-Medical Imaging, Sf. Apostol Andrei Emergency County Clinical Hospital Constanta, 900591 Constanta, Romania.
Diagnostics (Basel). 2022 Feb 12;12(2):473. doi: 10.3390/diagnostics12020473.
The COVID-19 disease, caused by infection with SARS-CoV-2, rapidly transformed into a pandemic following its emergence, and it continues to affect the population at a global level. This disease is associated with high mortality rates and mainly affects the pulmonary spectrum, with signs of interstitial pneumonia or other pathological modifications. Signs indicative of SARS-CoV-2 infection can be observed using pulmonary radiography or computed tomography scans and are closely linked to acute respiratory distress; however, there is accumulating evidence that the virus affects the central nervous system. Several symptoms, such as headaches, cough, fatigue, myalgia, ageusia, and anosmia, have also been reported along with neurological syndromes such as stroke, encephalopathy, Guillain-Barre syndrome, convulsions, and coma; the most frequent associated complication is ischemic stroke. Diagnosis of infection with SARS-CoV-2 virus is based on a positive RT-PCR test. Imaging investigations, such as thoracic computed tomography scans, are not used to diagnose COVID-19, monitor for pulmonary disease, or follow dynamic disease evolution, but they may be used in the case of a negative RT-PCR test. This paper presents the research performed on a group of 150 cases of patients affected by neurological disorders and that were subsequently confirmed to be infected with SARS-CoV-2, which was carried out over a period of 10 months within the Neurology Department and Laboratory of Magnetic Resonance Imaging of "Sf. Andrei" Emergency Hospital in Constanta. The collected data are observational and provide perspectives on the neurological pathology associated with the SARS-CoV-2 virus, and on the frequently associated risk factors, associated comorbidities, and the ages of patients who were affected by the virus, as well as the clinical and paraclinical manifestations of the patients admitted to the hospital's neurology department.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染引起的2019冠状病毒病（COVID-19）出现后迅速演变成一场大流行，并且仍在全球范围内影响着人群。这种疾病与高死亡率相关，主要影响肺部，表现为间质性肺炎或其他病理改变的迹象。使用肺部X光摄影或计算机断层扫描可以观察到表明SARS-CoV-2感染的迹象，这些迹象与急性呼吸窘迫密切相关；然而，越来越多的证据表明该病毒会影响中枢神经系统。还报告了一些症状，如头痛、咳嗽、疲劳、肌痛、味觉丧失和嗅觉丧失，以及中风、脑病、吉兰-巴雷综合征、惊厥和昏迷等神经综合征；最常见的相关并发症是缺血性中风。SARS-CoV-2病毒感染的诊断基于逆转录聚合酶链反应（RT-PCR）检测呈阳性。胸部计算机断层扫描等影像学检查不用于诊断COVID-19、监测肺部疾病或跟踪疾病的动态演变，但在RT-PCR检测呈阴性的情况下可能会使用。本文介绍了对一组150例患有神经疾病并随后被确诊感染SARS-CoV-2的患者进行的研究，该研究在康斯坦察“圣安德烈”急诊医院神经内科和磁共振成像实验室进行，为期10个月。收集的数据是观察性的，提供了与SARS-CoV-2病毒相关的神经病理学、常见相关危险因素、相关合并症、受该病毒影响患者的年龄，以及入住医院神经内科患者的临床和辅助检查表现等方面的观点。
