Lai Shi Min Shereen, Liew Sook Yee, Chear Nelson Jeng Yeou, Goh Bey Hing, Tan Wen-Nee, Khaw Kooi Yeong
School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Malaysia.
Chemistry Division, Centre for Foundation Studies in Science, University of Malaya, Kuala Lumpur 50603, Malaysia.
Biology (Basel). 2022 Feb 14;11(2):307. doi: 10.3390/biology11020307.
Plant-derived terpenes are the prolific source of modern drugs such as taxol, chloroquine and artemisinin, which are widely used to treat cancer and malaria infections. There are research interests in recent years on terpene-derived metabolites (diterpenes, triterpenes and sesquiterpenes), which are believed to serve as excellent cholinesterase inhibitors. As cholinesterase inhibitors are the current treatment for Alzheimer's disease, terpene-derived metabolites will have the potential to be involved in the future drug development for Alzheimer's disease. Hence, a bibliographic search was conducted by using the keywords "terpene", "cholinesterase" and "Alzheimer's disease", along with cross-referencing from 2011 to 2020, to provide an overview of natural terpenes with potential anticholinesterase properties. This review focuses on the extraction, chemical structures and anti-cholinesterase mechanisms of terpenes, which support and encourage future research on drug discovery and development in treating Alzheimer's disease.
植物源萜类化合物是现代药物的丰富来源，如紫杉醇、氯喹和青蒿素，这些药物被广泛用于治疗癌症和疟疾感染。近年来，人们对萜类衍生代谢物（二萜、三萜和倍半萜）产生了研究兴趣，据信它们是优秀的胆碱酯酶抑制剂。由于胆碱酯酶抑制剂是目前治疗阿尔茨海默病的药物，萜类衍生代谢物将有可能参与未来阿尔茨海默病的药物开发。因此，通过使用关键词“萜类”、“胆碱酯酶”和“阿尔茨海默病”进行文献检索，并对2011年至2020年的文献进行交叉引用，以概述具有潜在抗胆碱酯酶特性的天然萜类化合物。本综述重点关注萜类化合物的提取、化学结构和抗胆碱酯酶机制，这些支持并鼓励未来在治疗阿尔茨海默病的药物发现和开发方面的研究。
