Graduate School of Frontier Biosciences, Osaka University, Suita 565-0871, Japan.
Genes (Basel). 2022 Jan 22;13(2):200. doi: 10.3390/genes13020200.
Meiosis is critically different from mitosis in that during meiosis, pairing and segregation of homologous chromosomes occur. During meiosis, the morphology of sister chromatids changes drastically, forming a prominent axial structure in the synaptonemal complex. The meiosis-specific cohesin complex plays a central role in the regulation of the processes required for recombination. In particular, the Rec8 subunit of the meiotic cohesin complex, which is conserved in a wide range of eukaryotes, has been analyzed for its function in modulating chromosomal architecture during the pairing and recombination of homologous chromosomes in meiosis. Here, we review the current understanding of Rec8 cohesin as a structural platform for meiotic chromosomes.
减数分裂与有丝分裂有很大的不同，因为在减数分裂过程中会发生同源染色体的配对和分离。在减数分裂过程中，姐妹染色单体的形态发生剧烈变化，在联会复合体中形成明显的轴结构。减数分裂特异性黏合蛋白复合物在调节重组所需的过程中发挥核心作用。特别是，在广泛的真核生物中保守的减数分裂黏合蛋白复合物的 Rec8 亚基，其功能已被分析用于调节减数分裂中同源染色体配对和重组过程中的染色体结构。在这里，我们回顾了 Rec8 黏合蛋白作为减数分裂染色体结构平台的当前理解。
