Peersmann Shosha H M, Grootenhuis Martha A, van Straten Annemieke, Kerkhof Gerard A, Tissing Wim J E, Abbink Floor, de Vries Andrica C H, Loonen Jacqueline, Kremer Leontien C M, Kaspers Gertjan J L, van Litsenburg Raphaële R L
Princess Máxima Center for Pediatric Oncology, P.O. Box 85090, 3508 AB Utrecht, The Netherlands.
Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit, Pediatric Oncology, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
Cancers (Basel). 2022 Feb 13;14(4):926. doi: 10.3390/cancers14040926.
Sleep disorders negatively impact adolescent and young adult childhood cancer patients' physical and psychosocial health. Early recognition improves timely treatment. We therefore studied the prevalence of subjective sleep disorders, risk factors and sleep treatment needs after completion of childhood cancer treatment.
Childhood cancer patients (12-26 years old), ≥6 months after treatment, were invited to fill out the Holland Sleep Disorders Questionnaire, which distinguishes six sleep disorders in substantial agreement with the International Classification of Sleep Disorders, second edition (ICSD-2). They additionally indicated sleep treatment needs. Prevalence rates and needs were displayed in percentages. Logistic regression models were used for risk factors.
576 patients participated (response rate 55.8%)-49.5% females, mean age 17.0 years, 44.4% hemato-oncology, 31.9% solid tumors, 23.6% neuro-oncology. Prevalence rates were: insomnia (9.6%), circadian rhythm sleep disorder (CRSD; 8.1%), restless legs syndrome (7.6%), parasomnia (3.5%), hypersomnia (3.5%) and sleep-related breathing disorders (1.8%). Female sex, comorbid health conditions and young adulthood seem to be risk factors for sleep disorders, but cancer-related factors were not. Differing per sleep disorder, 42-72% wanted help, but only 0-5.6% received sleep treatment.
Insomnia and CRSD were most prevalent. An unmet need for sleep treatment was reported by childhood cancer patients during follow-up. Screening for sleep disorders after cancer might improve access to treatment and patient wellbeing.
睡眠障碍会对青少年及青年期儿童癌症患者的身心健康产生负面影响。早期识别有助于及时治疗。因此，我们研究了儿童癌症治疗结束后主观睡眠障碍的患病率、危险因素及睡眠治疗需求。
邀请治疗结束后≥6个月的12 - 26岁儿童癌症患者填写荷兰睡眠障碍问卷，该问卷可区分出六种与《国际睡眠障碍分类》第二版（ICSD - 2）基本一致的睡眠障碍。患者还需表明睡眠治疗需求。患病率及需求以百分比形式呈现。采用逻辑回归模型分析危险因素。
576名患者参与研究（应答率55.8%），其中女性占49.5%，平均年龄17.0岁，血液肿瘤患者占44.4%，实体瘤患者占31.9%，神经肿瘤患者占23.6%。患病率分别为：失眠（9.6%）、昼夜节律睡眠障碍（CRSD；8.1%）、不宁腿综合征（7.6%）、异态睡眠（3.5%）、嗜睡症（3.5%）及睡眠相关呼吸障碍（1.8%）。女性、合并健康问题及青年期似乎是睡眠障碍的危险因素，但与癌症相关的因素并非如此。不同睡眠障碍患者中，42% - 72%希望获得帮助，但只有0 - 5.6%接受了睡眠治疗。
失眠和CRSD最为常见。儿童癌症患者在随访期间报告了未满足的睡眠治疗需求。癌症后筛查睡眠障碍可能会改善治疗途径并提高患者的幸福感。
