皮肤癣菌可诱导人中性粒细胞释放中性粒细胞胞外诱捕网。
The Dermatophyte Induces Neutrophil Extracellular Traps Release by Human Neutrophils.
作者信息
Reis Ana Paula Carvalho, Celestrino Giovanna Azevedo, Igoa Mariana Villas Bôas, Jesus Thais Martins, França Tábata Takahashi, Moreira Daniel Valério Silva, Rigato Paula Ordonhez, Sato Paula Keiko, Condino-Neto Antonio, Noronha Irene L, Dias-Melicio Luciane Alarcão, Lalwani Pritesh Jaychand, Benard Gil, Sousa Maria Gloria Teixeira
机构信息
Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Clínicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of São Paulo, São Paulo 05403-000, Brazil.
Laboratory of Cellular, Genetic and Molecular Nephrology, Division of Nephrology, University of São Paulo School of Medicine, São Paulo 05403-000, Brazil.
出版信息
J Fungi (Basel). 2022 Jan 31;8(2):147. doi: 10.3390/jof8020147.
Neutrophils are the first leukocytes recruited to the site of infection and are thought to be responsible for fungal elimination from the skin such as dermatophytes. Neutrophils are able to secrete reactive oxygen species (ROS) and neutrophil extracellular traps (NETs) that can kill different fungi, including , spp., , and . However, NET production in response to , the main etiologic agent of dermatophytosis, has yet to be studied. We demonstrated that human neutrophils produce NETs against different morphotypes of in a dose-dependent manner and NET formation is dependent on ROS production. In addition, ROS production by human neutrophils in response to is dependent on NADPH oxidase, but not on fungal viability. NETs mediated killing of Collectively, these results demonstrate that was able to trigger the production of NETs, suggesting that these extracellular structures may represent an important innate immune effector mechanism controlling physiological response to infection.
中性粒细胞是最早被招募到感染部位的白细胞，被认为负责从皮肤清除真菌，如皮肤癣菌。中性粒细胞能够分泌活性氧（ROS）和中性粒细胞胞外陷阱（NETs），它们可以杀死不同的真菌，包括、 spp.、和。然而，针对皮肤癣菌病的主要病原体——，NET的产生尚未得到研究。我们证明，人类中性粒细胞以剂量依赖的方式针对不同形态的产生NETs，并且NET的形成依赖于ROS的产生。此外，人类中性粒细胞对的ROS产生依赖于NADPH氧化酶，而不依赖于真菌的活力。NETs介导了对的杀伤。总的来说，这些结果表明能够触发NETs的产生，这表明这些细胞外结构可能代表了一种重要的固有免疫效应机制，可控制对感染的生理反应。
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