法国科西嘉岛大学人群在第二波疫情期间 SARS-CoV-2 抗体血清阳性相关暴露因素的横断面研究。
A Cross-Sectional Study of Exposure Factors Associated with Seropositivity for SARS-CoV-2 Antibodies during the Second Epidemic Wave among a Sample of the University of Corsica (France).
机构信息
Laboratoire de Virologie, Université de Corse Pascal Paoli, UR7310 Bioscope, 20250 Corte, France.
INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, IPLESP, 75012 Paris, France.
出版信息
Int J Environ Res Public Health. 2022 Feb 10;19(4):1953. doi: 10.3390/ijerph19041953.
UNLABELLED
This study aimed to estimate the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection within the staff and student populations of the University of Corsica (France) during the second wave of the epidemic.
METHODS
A cross-sectional survey was conducted from 23 November 2020 to 31 January 2021. The participants underwent blood sampling using a fingerstick procedure and completed an anonymized questionnaire. Sera were tested for the presence of anti-SARS-CoV-2 IgG (ELISA-S) and, if positive, with an in-house virus neutralization test (VNT).
RESULTS
A total of 418 persons were included in the study. The overall seroprevalence was 12.8% (95% confidence interval (CI), 9.8-16.6%). A total of 15 (31%) of the 49 individuals who had a positive ELISA-S also had a positive VNT. Seropositivity was associated with living at the city campus during the week and on weekends (OR = 3.74 [1.40-12.00]), using public transportation/carpooling (OR = 2.00 [1.01-4.02]), and being in contact with a person who tested positive for SARS-CoV-2 (OR = 2.32 [1.20-4.40]). The main symptoms associated with seropositivity were "having had an acute respiratory infection" (OR = 3.05 [1.43-6.43]) and "experiencing loss of smell" (OR = 16.4 [5.87-50.7]).
CONCLUSION
These results could be useful for SARS-CoV-2 prevention and control on university campuses.
目的
本研究旨在评估法国科西嘉大学（University of Corsica）教职员工和学生群体在疫情第二波期间的严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）感染血清流行率。
方法
于 2020 年 11 月 23 日至 2021 年 1 月 31 日开展横断面调查。通过手指采血程序采集参与者的血液样本，并完成匿名问卷。使用酶联免疫吸附试验（ELISA-S）检测血清中是否存在抗 SARS-CoV-2 IgG，如果为阳性，则使用内部病毒中和试验（VNT）进行检测。
结果
共纳入 418 人。总体血清流行率为 12.8%（95%置信区间，9.8-16.6%）。在 49 例 ELISA-S 阳性者中，共有 15 例（31%）VNT 也为阳性。血清阳性与工作日和周末在城市校区居住（比值比[OR] = 3.74[1.40-12.00]）、使用公共交通工具/拼车（OR = 2.00[1.01-4.02]）和与 SARS-CoV-2 检测呈阳性的人接触（OR = 2.32[1.20-4.40]）有关。与血清阳性相关的主要症状是“急性呼吸道感染”（OR = 3.05[1.43-6.43]）和“嗅觉丧失”（OR = 16.4[5.87-50.7]）。
结论
这些结果可能对大学校园内 SARS-CoV-2 的预防和控制有用。
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