Galmiche Simon, Charmet Tiffany, Schaeffer Laura, Paireau Juliette, Grant Rebecca, Chény Olivia, Von Platen Cassandre, Maurizot Alexandra, Blanc Carole, Dinis Annika, Martin Sophie, Omar Faïza, David Christophe, Septfons Alexandra, Cauchemez Simon, Carrat Fabrice, Mailles Alexandra, Levy-Bruhl Daniel, Fontanet Arnaud
Institut Pasteur, Emerging Diseases Epidemiology Unit, Paris, France.
Institut Pasteur, Mathematical Modelling of Infectious Diseases Unit; UMR2000; CNRS, Paris, France.
Lancet Reg Health Eur. 2021 Aug;7:100148. doi: 10.1016/j.lanepe.2021.100148. Epub 2021 Jun 7.
We aimed to assess the role of different setting and activities in acquiring SARS-CoV-2 infection.
In this nationwide case-control study, cases were SARS-CoV-2 infected adults recruited between 27 October and 30 November 2020. Controls were individuals from the Ipsos market research database matched to cases by age, sex, region, population density and time period. Participants completed an online questionnaire on recent activity-related exposures.
Among 3426 cases and 1713 controls, in multivariable analysis, we found an increased risk of infection associated with any additional person living in the household (adjusted-OR: 1•16; 95%CI: 1•11-1•21); having children attending day-care (aOR: 1•31; 95%CI: 1•02-1•62), kindergarten (aOR: 1•27; 95%CI: 1•09-1•45), middle school (aOR: 1•30; 95%CI: 1•15-1•47), or high school (aOR: 1•18; 95%CI: 1•05-1•34); with attending professional (aOR: 1•15; 95%CI: 1•04-1•26) or private gatherings (aOR: 1•57; 95%CI: 1•45-1•71); and with having frequented bars and restaurants (aOR: 1•95; 95%CI: 1•76-2•15), or having practiced indoor sports activities (aOR: 1•36; 95%CI: 1•15-1•62). We found no increase in risk associated with frequenting shops, cultural or religious gatherings, or with transportation, except for carpooling (aOR: 1•47; 95%CI: 1•28-1•69). Teleworking was associated with decreased risk of infection (aOR: 0•65; 95%CI: 0•56-0•75).
Places and activities during which infection prevention and control measures may be difficult to fully enforce were those with increased risk of infection. Children attending day-care, kindergarten, middle and high schools, but not primary schools, were potential sources of infection for the household.
Institut Pasteur, Research & Action Emerging Infectious Diseases (REACTing), Fondation de France (Alliance" Tous unis contre le virus").
我们旨在评估不同场所和活动在感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）中的作用。
在这项全国性病例对照研究中，病例为2020年10月27日至11月30日期间招募的感染SARS-CoV-2的成年人。对照是益普索市场研究数据库中按年龄、性别、地区、人口密度和时间段与病例匹配的个体。参与者完成了一份关于近期与活动相关暴露的在线问卷。
在3426例病例和1713名对照中，多变量分析显示，与 household 中任何其他居住者相关的感染风险增加（调整后的比值比：1.16；95%置信区间：1.11 - 1.21）；家中有孩子上日托班（调整后的比值比：1.31；95%置信区间：1.02 - 1.62）、幼儿园（调整后的比值比：1.27；95%置信区间：1.09 - 1.45）、中学（调整后的比值比：1.30；95%置信区间：1.15 - 1.47）或高中（调整后的比值比：1.18；95%置信区间：1.05 - 1.34）；参加专业活动（调整后的比值比：1.15；95%置信区间：1.04 - 1.26）或私人聚会（调整后的比值比：1.57；95%置信区间：1.45 - 1.71）；经常光顾酒吧和餐馆（调整后的比值比：1.95；95%置信区间：1.76 - 2.15），或进行室内体育活动（调整后的比值比：1.36；95%置信区间：1.15 - 1.62）。我们发现，除拼车外（调整后的比值比：1.47；95%置信区间：1.28 - 1.69），经常光顾商店、参加文化或宗教聚会或乘坐交通工具与感染风险增加无关。远程工作与感染风险降低相关（调整后的比值比：0.65；95%置信区间：0.56 - 0.75）。
在那些可能难以全面实施感染预防和控制措施的场所和活动中，感染风险增加。上日托班、幼儿园、中学和高中但不上小学的儿童是家庭潜在的感染源。
巴斯德研究所、新兴传染病研究与行动组织（REACTing）、法国基金会（“团结抗击病毒”联盟）
