Okayama Akira, Nakayama Naomi, Kashiwa Kaori, Horinouchi Yutaka, Fukusaki Hayato, Nakamura Hirosuke, Katayama Satoru
Department of General Medicine and Community Health Science, School of Medicine, Hyogo College of Medicine, Sasayama Medical Center, Tanbasasayama 669-2321, Japan.
Faculty of Health and Nutrition, The University of Shimane, Izumo 693-8550, Japan.
Healthcare (Basel). 2022 Jan 19;10(2):192. doi: 10.3390/healthcare10020192.
In this cross-sectional analysis of 61 postmenopausal osteoporosis patients who regularly visited an osteoporosis outpatient clinic, we aimed to clarify the prevalence of sarcopenia and its related clinical factors. Of 61 patients (mean age 77.6 ± 8.1 years), 24 (39.3%) had osteosarcopenia and 37 (60.7%) had osteoporosis alone. Age, nutritional status, and the number of prescribed drugs were associated with the presence of sarcopenia ( = 0.002, <0.001, and 0.001, respectively), while bone mineral density (BMD) and % young adult mean BMD were not ( = 0.119 and 0.119, respectively). Moreover, patients with osteosarcopenia had lower quality of life (QOL) scores, greater postural instability, and a higher incidence of falls in the past year than patients with osteoporosis alone. In contrast, BMD status showed no correlation with the nutritional status, QOL score, postural instability, or incidence of falls in the past year. In conclusion, the incidence of sarcopenia was relatively high among postmenopausal osteoporosis female patients in an osteoporosis outpatient clinic. Our results suggest that in addition to routine BMD evaluation, assessment and management of sarcopenia may be promoted at osteoporosis outpatient clinics to limit the risk of falls and prevent consequent fragility fractures in osteoporosis patients.
在这项对61名定期前往骨质疏松门诊就诊的绝经后骨质疏松症患者的横断面分析中，我们旨在明确肌肉减少症的患病率及其相关临床因素。61名患者（平均年龄77.6±8.1岁）中，24名（39.3%）患有骨质疏松性肌肉减少症，37名（60.7%）仅患有骨质疏松症。年龄、营养状况和处方药数量与肌肉减少症的存在相关（分别为=0.002、<0.001和0.001），而骨密度（BMD）和%年轻成人平均BMD则无相关性（分别为=0.119和0.119）。此外，与仅患有骨质疏松症的患者相比，患有骨质疏松性肌肉减少症的患者生活质量（QOL）得分更低、姿势稳定性更差且过去一年跌倒发生率更高。相比之下，BMD状况与营养状况、QOL得分、姿势稳定性或过去一年跌倒发生率均无相关性。总之，在骨质疏松门诊中，绝经后骨质疏松女性患者中肌肉减少症的发生率相对较高。我们的结果表明，除了常规的BMD评估外，骨质疏松门诊可能需要加强对肌肉减少症的评估和管理，以降低跌倒风险并预防骨质疏松症患者随后发生的脆性骨折。
