de Vries Charlotte, Ruacho Guillermo, Kindstedt Elin, Potempa Barbara Aleksandra, Potempa Jan, Klinge Björn, Lundberg Pernilla, Svenungsson Elisabet, Lundberg Karin
Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden.
Public Dental Services, Folktandvården Stockholms Län AB, 113 82 Stockholm, Sweden.
J Clin Med. 2022 Feb 15;11(4):1008. doi: 10.3390/jcm11041008.
There is accumulating data suggesting that periodontitis is associated with increased risk of systemic and autoimmune diseases, including cardiovascular disease, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and there is an unmet need to identify these individuals early. With the periodontal bacteria () as one of the key drivers of periodontitis, we set out to investigate whether antibodies to virulence factor arginine gingipain (Rgp) could serve as a biomarker for periodontitis patients at increased risk of autoimmunity and systemic disease. We measured serum anti-Rgp IgG in three study populations: PAROKRANK (779 individuals with myocardial infarction (MI); 719 controls), where 557 had periodontitis, and 312 were positive for autoantibodies associated with RA/SLE; the PerioGene North pilot (41 periodontitis; 39 controls); and an SLE case/control study (101 SLE; 100 controls). Anti-Rgp IgG levels were increased in severe periodontitis compared to controls ( < 0.0001), in individuals positive for anti-citrullinated protein antibodies ( = 0.04) and anti-dsDNA antibodies ( = 0.035), compared to autoantibody-negative individuals; and in MI patients versus matched controls ( = 0.035). Our data support longitudinal studies addressing the role of anti-Rgp antibodies as biomarkers for periodontitis patients at increased risk of developing autoimmunity linked to RA and SLE, and mechanisms underpinning these associations.
越来越多的数据表明，牙周炎与包括心血管疾病、类风湿性关节炎（RA）和系统性红斑狼疮（SLE）在内的全身性和自身免疫性疾病风险增加有关，并且迫切需要尽早识别这些个体。鉴于牙周细菌（）是牙周炎的关键驱动因素之一，我们着手研究针对毒力因子精氨酸牙龈蛋白酶（Rgp）的抗体是否可作为自身免疫和全身性疾病风险增加的牙周炎患者的生物标志物。我们在三个研究人群中测量了血清抗Rgp IgG：PAROKRANK（779例心肌梗死（MI）患者；719名对照），其中557人患有牙周炎，312人抗RA/SLE相关自身抗体呈阳性；PerioGene North试点研究（41例牙周炎患者；39名对照）；以及一项SLE病例/对照研究（101例SLE患者；100名对照）。与对照相比，重度牙周炎患者的抗Rgp IgG水平升高（<0.0001），与自身抗体阴性个体相比，抗瓜氨酸化蛋白抗体阳性（=0.04）和抗双链DNA抗体阳性（=0.035）的个体抗Rgp IgG水平升高；与匹配对照相比，MI患者的抗Rgp IgG水平升高（=0.035）。我们的数据支持开展纵向研究，以探讨抗Rgp抗体作为自身免疫性疾病风险增加的牙周炎患者生物标志物的作用，以及这些关联背后的机制，这些自身免疫性疾病与RA和SLE相关。
