地西泮或硫利达嗪对与驾驶相关的精神运动技能的影响：一项针对神经症门诊患者的亚急性试验。
Modification by diazepam or thioridazine of the psychomotor skills related to driving: a subacute trial in neurotic out-patients.
作者信息
Saario I, Linnoila M, Mattila M J
出版信息
Br J Clin Pharmacol. 1976 Oct;3(5):843-8. doi: 10.1111/j.1365-2125.1976.tb00636.x.
Abstract
Forty-five out-patients with clinically manifested anxiety were tested in order to study the effects of 2 weeks' treatment with placebo, diazepam (5-10 mg three times daily) or thioridazine (25-50 mg three times daily) on their psychomotor skills related to driving. When compared with placebo, diazepam increased the number of mistakes in reaction and co-ordination tests and also decreased ability to discriminate the fusion of flickering light. When compared to other groups, reactive and co-ordinative skills were more impaired in patients treated with thioridazine which also impaired divided attention. Aubjectively thioridazine was not experienced as effective an anxiolytic as diazepam.
摘要
为研究安慰剂、地西泮（每日三次，每次5 - 10毫克）或硫利达嗪（每日三次，每次25 - 50毫克）治疗2周对45名有临床表现的焦虑症门诊患者与驾驶相关的心理运动技能的影响，对他们进行了测试。与安慰剂相比，地西泮增加了反应和协调测试中的错误数量，还降低了辨别闪烁光融合的能力。与其他组相比，硫利达嗪治疗的患者反应和协调技能受损更严重，且该药物还损害了注意力分散能力。主观上，硫利达嗪作为抗焦虑药的效果不如地西泮。
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