Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
Medicina (Kaunas). 2022 Jan 27;58(2):194. doi: 10.3390/medicina58020194.
: Vitamin D deficiency is involved in numerous pathologies, including endocrine pathology. The purpose of this review consists of presenting the role of vitamin D in the pathophysiology of certain endocrine disorders, autoimmune thyroid disorders (Hashimoto's disease and Grave's disease), diabetes mellitus, and obesity, and whether its supplementation can influence the outcome of these diseases. : Review articles and original articles from the literature were consulted that corresponded with the thematic. : Vitamin D deficiency is frequently encountered in endocrine disorders and supplementation restores the normal values. In Hashimoto's disease, vitamin D deficiency appears to be correlated with a higher titer of anti-TPO antibodies and with thyroid volume, and supplementation was associated with reduction of antibodies in some studies. In other studies, supplementation appeared to reduce TSH levels. In Grave's disease, there was a significant correlation regarding vitamin D levels and thyroid volume respective to the degree of exophthalmos. In diabetes mellitus type 2 patients, supplementation led to some improvement of the HOMA-IR index and HbA1c, whereas obesity data from literature do not report significant beneficial findings. : Vitamin D deficiency is highly prevalent in endocrine disorders and its supplementation appears to have numerous beneficial effects.
维生素 D 缺乏与许多疾病有关，包括内分泌病理学。本综述的目的是介绍维生素 D 在某些内分泌疾病（自身免疫性甲状腺疾病[桥本氏病和格雷夫斯病]、糖尿病和肥胖症]）的病理生理学中的作用，以及补充维生素 D 是否会影响这些疾病的结局。
检索了与主题相关的综述文章和原始文献。
维生素 D 缺乏在内分泌疾病中很常见，补充可恢复正常值。在桥本氏病中，维生素 D 缺乏似乎与更高的抗 TPO 抗体滴度和甲状腺体积相关，一些研究表明补充可降低抗体滴度。在其他研究中，补充似乎降低了 TSH 水平。在格雷夫斯病中，维生素 D 水平与眼球突出程度相关的甲状腺体积之间存在显著相关性。在 2 型糖尿病患者中，补充后 HOMA-IR 指数和 HbA1c 有所改善，而文献中的肥胖数据未报告显著的有益发现。
维生素 D 缺乏在内分泌疾病中非常普遍，补充似乎有许多有益的作用。
