Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.
Nutrients. 2023 Aug 25;15(17):3725. doi: 10.3390/nu15173725.
Studies indicate a high prevalence of vitamin D deficiency in both the general population and at-risk groups. Given the association between vitamin D deficiency and various diseases, addressing this concern becomes crucial, especially in situations where routine monitoring is challenging.
A systematic literature review of the current knowledge on vitamin D dosing in diverse at-risk populations and the application of the findings to a broader clinical perspective.
The reviewed studies revealed a high prevalence of vitamin D deficiency among patients with musculoskeletal disorders, systemic connective tissue diseases, corticosteroid use, endocrine and metabolic conditions, malabsorption syndromes, obesity, chronic kidney disease, cancer, and central nervous system diseases. Vitamin D deficiency was often more severe compared to the general population. Higher dosages of vitamin D beyond the recommended levels for the general population were shown to be effective in improving vitamin D status in these at-risk individuals. Additionally, some studies suggested a potential link between intermittent vitamin D administration and improved adherence.
Simplified dosing could empower clinicians to address vitamin D deficiency, particularly in high-risk populations, even without routine monitoring. Further research is needed to establish the optimal dosing regimens for specific at-risk populations.
研究表明，普通人群和高危人群普遍存在维生素 D 缺乏症。鉴于维生素 D 缺乏与各种疾病之间存在关联，解决这一问题至关重要，特别是在常规监测具有挑战性的情况下。
对不同高危人群中维生素 D 剂量的现有知识进行系统文献回顾，并将研究结果应用于更广泛的临床角度。
综述研究表明，患有肌肉骨骼疾病、系统性结缔组织疾病、皮质类固醇使用、内分泌和代谢疾病、吸收不良综合征、肥胖症、慢性肾脏病、癌症和中枢神经系统疾病的患者中维生素 D 缺乏症的患病率较高。与普通人群相比，这些高危人群的维生素 D 缺乏症往往更为严重。较高剂量的维生素 D 超过普通人群的推荐水平，可有效改善这些高危个体的维生素 D 状况。此外，一些研究表明，间歇性给予维生素 D 与改善依从性之间存在潜在联系。
简化的剂量方案可以使临床医生能够解决维生素 D 缺乏症的问题，尤其是在高危人群中，即使没有常规监测也可以做到。需要进一步研究以确定特定高危人群的最佳剂量方案。
