Eltz H, Aeschlimann J, Gloor B
Acta Ophthalmol (Copenh). 1978 Apr;56(2):191-200. doi: 10.1111/j.1755-3768.1978.tb01345.x.
In a double-blind cross-over study, the intraocular pressure-lowering action and side effects of a 5% guanethidine/1% adrenaline combination were studied and compared with those of two components alone. The subjects were 63 glaucoma patients divided into three random groups given the three preparations in a different order. The pressure-lowering effect of the combination is significantly better (P less than 1%) than that of either component alone but the side effects were more severe.
在一项双盲交叉研究中，对5%胍乙啶/1%肾上腺素组合降低眼压的作用和副作用进行了研究，并与单独使用两种成分的情况进行了比较。研究对象为63例青光眼患者，随机分为三组，以不同顺序给予三种制剂。该组合降低眼压的效果明显优于单独使用任何一种成分（P小于1%），但其副作用更严重。
