Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai Nishi, Miyazaki 889-2192, Japan.
Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai Nishi, Miyazaki 889-2192, Japan.
Molecules. 2022 Feb 14;27(4):1271. doi: 10.3390/molecules27041271.
Diets with high daily fat consumption are associated with excess weight. However, the effects of fat type and consumption timing on excess weight remain unclear. We investigated the selection of a 30% (/) fat diet of soybean oil (SOY), lard (LARD), and fish oil (FISH) on the metabolic parameters of mice. Male C57BL/6 mice were divided into the double SOY-box (w-SOY), SOY-box/LARD-box (SOY-vs-LARD), or SOY-box/FISH-box (SOY-vs-FISH) groups and allowed to selectively consume for 8 weeks. The total energy intake was similar for all groups, but the mice selectively chose to consume LARD over SOY and SOY over FISH. Body weight in the SOY-vs-LARD group was significantly higher than that in the w-SOY and SOY-vs-FISH groups. Additionally, minimal but selective consumption of an omega-3 fatty-acid-rich FISH diet at the end of the active period increased the physiological fatty acid compositions of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the SOY-vs-FISH group; their metabolic parameters were also lower than the SOY-vs-LARD group. In conclusion, selectively consuming small amounts of fish oil at the end of the day may prevent excess weight compared with LARD consumption.
高日脂肪摄入量的饮食与超重有关。然而，脂肪类型和摄入时间对超重的影响仍不清楚。我们研究了选择 30%（/）脂肪饮食的大豆油（SOY）、猪油（LARD）和鱼油（FISH）对小鼠代谢参数的影响。雄性 C57BL/6 小鼠分为双 SOY 盒（w-SOY）、SOY 盒/猪油盒（SOY-vs-LARD）或 SOY 盒/鱼油盒（SOY-vs-FISH）组，并允许其选择性地消耗 8 周。所有组的总能量摄入相似，但小鼠选择性地选择消耗猪油而不是 SOY，消耗 SOY 而不是 FISH。SOY-vs-LARD 组的体重明显高于 w-SOY 和 SOY-vs-FISH 组。此外，在活跃期结束时对富含ω-3 脂肪酸的 FISH 饮食进行微量但选择性的消耗，增加了 SOY-vs-FISH 组中二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的生理脂肪酸组成；它们的代谢参数也低于 SOY-vs-LARD 组。总之，与消耗猪油相比，在一天结束时选择性地摄入少量鱼油可能有助于预防超重。
