Ahmed Saima, Lévesque Emmanuelle, Garland Rosalind, Knoppers Bartha, Dorval Michel, Simard Jacques, Loiselle Carmen G
Division of Experimental Medicine, McGill University, Montréal, QC, Canada.
CIUSSS Centre-Ouest Montréal, Segal Cancer Centre, Jewish General Hospital, Montreal, QC, Canada.
Hered Cancer Clin Pract. 2022 Feb 24;20(1):8. doi: 10.1186/s13053-022-00214-4.
Breast cancer risk stratification categorizes a woman's potential risk of developing the disease as near-population, intermediate, or high. In accordance, screening and follow up for breast cancer can readily be tailored following risk assessment. Recent efforts have focussed on developing more accessible means to convey this information to women. This study sought to document the relevance of an informational e-platform developed for these purposes.
To begin to assess a newly developed breast cancer risk stratification and decision support e-platform called PERSPECTIVE (PErsonalised Risk Stratification for Prevention and Early deteCTIon of breast cancer) among women who do not know their personal breast cancer risk (Phase 1). Changes (pre- and post- e-platform exposure) in knowledge of breast cancer risk and interest in undergoing genetic testing were assessed in addition to perceptions of platform usability and acceptability.
Using a pre-post design, women (N = 156) of differing literacy and education levels, aged 30 to 60, with no previous breast cancer diagnosis were recruited from the general population and completed self-report e-questionnaires.
Mean e-platform viewing time was 18.67 min (SD 0.65) with the most frequently visited pages being breast cancer-related risk factors and risk assessment. Post-exposure, participants reported significantly higher breast cancer-related knowledge (p < .001). Increases in knowledge relating to obesity, alcohol, breast density, menstruation, and the risk estimation process remained even when sociodemographic variables age and education were controlled. There were no significant changes in genetic testing interest post-exposure. Mean ratings for e-platform acceptability and usability were high: 26.19 out of 30 (SD 0.157) and 42.85 out of 50 (SD 0.267), respectively.
An informative breast cancer risk stratification e-platform targeting healthy women in the general population can significantly increase knowledge as well as support decisions around breast cancer risk and assessment. Currently underway, Phase 2, called PERSPECTIVE, is seeking further content integration and broader implementation .
乳腺癌风险分层将女性患该疾病的潜在风险分为接近总体风险、中等风险或高风险。据此，乳腺癌的筛查和随访可以在风险评估后轻松进行调整。最近的努力集中在开发更易于获取的方式，将这些信息传达给女性。本研究旨在记录为这些目的开发的信息电子平台的相关性。
在不了解自身乳腺癌风险的女性中（第1阶段），开始评估一个新开发的名为PERSPECTIVE（个性化乳腺癌预防和早期检测风险分层）的乳腺癌风险分层和决策支持电子平台。除了对平台可用性和可接受性的认知外，还评估了（在接触电子平台前后）乳腺癌风险知识的变化以及进行基因检测的兴趣。
采用前后设计，从普通人群中招募年龄在30至60岁、识字和教育水平不同、既往无乳腺癌诊断的女性（N = 156），并完成自我报告电子问卷。
电子平台的平均浏览时间为18.67分钟（标准差0.65），访问最频繁的页面是与乳腺癌相关的风险因素和风险评估。接触电子平台后，参与者报告的乳腺癌相关知识显著增加（p < 0.001）。即使在控制了社会人口统计学变量年龄和教育程度后，与肥胖、酒精、乳腺密度、月经和风险估计过程相关的知识仍有所增加。接触电子平台后，进行基因检测的兴趣没有显著变化。电子平台可接受性和可用性的平均评分很高：分别为30分中的26.19分（标准差0.157）和50分中的42.85分（标准差0.267）。
一个针对普通人群中健康女性的信息丰富的乳腺癌风险分层电子平台可以显著增加知识，并支持围绕乳腺癌风险和评估的决策。目前正在进行的第2阶段，即PERSPECTIVE，正在寻求进一步的内容整合和更广泛的实施。
