Chen Feifan, He Yalin, Shi Yuan
Department of Neonatology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
Vaccines (Basel). 2022 Jan 24;10(2):179. doi: 10.3390/vaccines10020179.
COVID-19 vaccination for children is crucial to achieve herd immunity. This is the first systematic review and meta-analysis to estimate parents' and guardians' willingness to vaccinate their children against COVID-19 and identify the determinants of vaccination intention. Systematic research was performed on the two databases (PubMed and EMBASE) from inception to 6 November 2021. Acceptance rates were pooled by use of a random-effects model and all predictors of vaccine acceptance were identified according to the health belief model (HBM) framework. This analysis was registered with PROSPERO (CRD42021292326) and reported in compliance with the PRISMA guidelines. Of 452 identified records, 29 eligible studies were included (N = 68,327 participants). The estimated worldwide vaccination acceptance rate was 61.40% (95% CI: 53.56-68.69%, I = 99.3%), ranging from 21.6% to 91.4% across countries and regions. In the determinant assessment, the age of parents and guardians, access to scientific information and recommendations, routine and influenza vaccination behavior, and the willingness of parents and guardians to vaccinate themselves were potentially significant predictors of the vaccination willingness. Given the limited quality and quantity of included articles, future studies with a rigorous design will be necessary for the confirmation of our findings.
儿童接种新冠疫苗对于实现群体免疫至关重要。这是第一项系统评价和荟萃分析，旨在估计父母和监护人让其子女接种新冠疫苗的意愿，并确定接种意愿的决定因素。对两个数据库（PubMed和EMBASE）从创建到2021年11月6日进行了系统检索。采用随机效应模型汇总接受率，并根据健康信念模型（HBM）框架确定疫苗接受的所有预测因素。该分析已在PROSPERO（CRD42021292326）注册，并按照PRISMA指南报告。在452条识别记录中，纳入了29项符合条件的研究（N = 68327名参与者）。全球估计的疫苗接种接受率为61.40%（95%CI：53.56 - 68.69%，I² = 99.3%），各国和各地区的接受率在21.6%至91.4%之间。在决定因素评估中，父母和监护人的年龄、获取科学信息和建议的情况、常规和流感疫苗接种行为以及父母和监护人自身的接种意愿是接种意愿的潜在重要预测因素。鉴于纳入文章的质量和数量有限，未来需要进行设计严谨的研究来证实我们的发现。
