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新冠疫苗接种后新发肾脏疾病：病例系列

New-Onset Kidney Diseases after COVID-19 Vaccination: A Case Series.

作者信息

Lim Jeong-Hoon, Kim Mee-Seon, Kim Yong-Jin, Han Man-Hoon, Jung Hee-Yeon, Choi Ji-Young, Cho Jang-Hee, Kim Chan-Duck, Kim Yong-Lim, Park Sun-Hee

机构信息

Division of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Korea.

Department of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Korea.

出版信息

Vaccines (Basel). 2022 Feb 16;10(2):302. doi: 10.3390/vaccines10020302.

DOI:10.3390/vaccines10020302
PMID:35214760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8880359/
Abstract

Various vaccines against COVID-19 have been developed and proven to be effective, but their side effects, especially on kidney function, are not yet known in detail. In this study, we report the clinical courses and histopathologic findings of new-onset kidney diseases after COVID-19 vaccination as confirmed via kidney biopsy. Five patients aged 42 to 77 years were included in this study, and baseline kidney function was normal in all patients. The biopsy-proven diagnosis indicated newly developed kidney diseases: (1) IgA nephropathy presenting with painless gross hematuria, (2) minimal change disease presenting with nephrotic syndrome, (3) thrombotic microangiopathy, and (4) two cases of acute tubulointerstitial nephritis presenting with acute kidney injury. Individualized treatment was applied as per disease severity and underlying pathology, and the treatment outcomes of all patients were improved. Since this is not a controlled study, the specific pathophysiologic link and causality between the incidence of kidney diseases and COVID-19 vaccination are difficult to confirm. However, clinicians need to consider the possibility that kidney diseases may be provoked by vaccines in patients who have renal symptoms.

摘要

已经研发出多种针对新型冠状病毒肺炎（COVID-19）的疫苗并证明其有效，但它们的副作用，尤其是对肾功能的副作用，目前尚不清楚。在本研究中，我们报告了经肾活检确诊的COVID-19疫苗接种后新发肾脏疾病的临床病程和组织病理学结果。本研究纳入了5例年龄在42至77岁之间的患者，所有患者的基线肾功能均正常。活检证实的诊断表明出现了新发肾脏疾病：（1）表现为无痛性肉眼血尿的IgA肾病，（2）表现为肾病综合征的微小病变病，（3）血栓性微血管病，以及（4）两例表现为急性肾损伤的急性肾小管间质性肾炎。根据疾病严重程度和潜在病理情况进行个体化治疗，所有患者的治疗结果均得到改善。由于这不是一项对照研究，肾脏疾病发病率与COVID-19疫苗接种之间的具体病理生理联系和因果关系难以确定。然而，临床医生需要考虑在有肾脏症状的患者中，肾脏疾病可能由疫苗诱发的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/8880359/a7cc341f5c83/vaccines-10-00302-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/8880359/915caccaa99d/vaccines-10-00302-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/8880359/23ff21ce67f9/vaccines-10-00302-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/8880359/a7ef93d928d9/vaccines-10-00302-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/8880359/a7a77b3baf08/vaccines-10-00302-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/8880359/a7cc341f5c83/vaccines-10-00302-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/8880359/915caccaa99d/vaccines-10-00302-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/8880359/23ff21ce67f9/vaccines-10-00302-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/8880359/a7ef93d928d9/vaccines-10-00302-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/8880359/a7a77b3baf08/vaccines-10-00302-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f84/8880359/a7cc341f5c83/vaccines-10-00302-g005.jpg

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