大肠杆菌中质粒介导的对红霉素的高水平抗性
Plasmid-mediated high-level resistance to erythromycin in Escherichia coli.
作者信息
Andremont A, Gerbaud G, Courvalin P
出版信息
Antimicrob Agents Chemother. 1986 Mar;29(3):515-8. doi: 10.1128/AAC.29.3.515.
Abstract
Escherichia coli BM2195 was found to be resistant to high levels of erythromycin. This new resistance phenotype was due to the constitutive synthesis of an erythromycin esterase which inactivates the antibiotic. The gene conferring resistance to erythromycin in this strain is carried on a 61-kilobase self-transferable plasmid, pIP1100, belonging to incompatibility group X.
摘要
发现大肠杆菌BM2195对高浓度红霉素具有抗性。这种新的抗性表型是由于组成型合成了一种使抗生素失活的红霉素酯酶。赋予该菌株对红霉素抗性的基因位于一个61千碱基的可自我转移质粒pIP1100上，该质粒属于不相容群X。
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