Barthélémy P, Autissier D, Gerbaud G, Courvalin P
J Antibiot (Tokyo). 1984 Dec;37(12):1692-6. doi: 10.7164/antibiotics.37.1692.
Escherichia coli BM2195 is highly resistant to erythromycin by inactivation of the antibiotic. We have determined the structure of the modified antibiotic by physico-chemical techniques including mass spectrometry, infrared spectrophotometry, 13C nuclear magnetic resonance, and circular dichroism. The results obtained indicate that E. coli BM2195 resists erythromycin by the production of an erythromycin esterase which hydrolyzes the lactone ring of the antibiotic.
大肠杆菌BM2195通过使抗生素失活而对红霉素具有高度抗性。我们已经通过包括质谱分析、红外分光光度法、13C核磁共振和圆二色性在内的物理化学技术确定了修饰后抗生素的结构。所获得的结果表明，大肠杆菌BM2195通过产生一种红霉素酯酶来抵抗红霉素，该酯酶可水解抗生素的内酯环。
