动物源产气荚膜梭菌对大环内酯-林可酰胺-链阳菌素的耐药模式
Macrolide-lincosamide-streptogramin resistance patterns in Clostridium perfringens from animals.
作者信息
Dutta G N, Devriese L A
出版信息
Antimicrob Agents Chemother. 1981 Feb;19(2):274-8. doi: 10.1128/AAC.19.2.274.
Different patterns of resistance against commonly used macrolide, lincosamide, and streptogramin antibiotics were found in Clostridium perfringens of animal origin. The patterns were designated as (i) macrolide-lincosamide-streptogramin group B generalized resistance, (ii) macrolide-lincosamide generalized resistance, (iii) macrolide-lincosamide inducible resistance, and (iv) macrolide-lincosamide-streptogramin low-level generalized resistance. The strains of the fourth pattern were able to inactivate pristinamycin and virginiamycin. The macrolide-susceptible strains showed a bimodal distribution of lincomycin and clindamycin susceptibility levels. The susceptible strains were inhibited by 0.25 micrograms of lincomycin per ml and 0.03 micrograms of clindamycin per ml. The low-level resistant strains were inhibited at concentrations of 2 to 4 micrograms of lincomycin per ml and 0.5 to 2 micrograms of clindamycin per ml.
在动物源产气荚膜梭菌中发现了对常用大环内酯类、林可酰胺类和链阳菌素类抗生素的不同耐药模式。这些模式被指定为：（i）大环内酯-林可酰胺-链阳菌素B组广泛耐药；（ii）大环内酯-林可酰胺广泛耐药；（iii）大环内酯-林可酰胺诱导耐药；以及（iv）大环内酯-林可酰胺-链阳菌素低水平广泛耐药。第四种模式的菌株能够使 pristinamycin 和维吉尼亚霉素失活。大环内酯敏感菌株的林可霉素和克林霉素敏感性水平呈双峰分布。敏感菌株被每毫升0.25微克的林可霉素和每毫升0.03微克的克林霉素抑制。低水平耐药菌株在每毫升2至4微克林可霉素和每毫升0.5至2微克克林霉素的浓度下被抑制。
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