Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
Nutrients. 2022 Feb 15;14(4):814. doi: 10.3390/nu14040814.
, commonly known as frankincense, has been used for centuries as a natural anti-inflammatory and anti-microbial remedy for many illnesses. However, the effect of the bioactive ingredient of it, 3-O-acetyl-11-keto-b-boswellic acid (AKBA), on both the gut microbiome and blood metabolites, is not known. In this study, we observe the effect of this isolated active ingredient orally on both male and female mice. Gut microbiota and blood metabolites were determined at the beginning and end of a 14-day consumption period. AKBA significantly decreased gut bacterial richness in male mice, and had no effect on female mice. , associated with weight loss and anti-inflammation, was found to be significantly increased in both male and female mice, along with an increase in in female mice. and were plated on media containing varying levels of AKBA (0%, 0.001%, 0.01%, and 0.1%). All concentrations of AKBA completely inhibited growth of but had no effect on . Several blood metabolites differed with AKBA between both males and females. These results show the potential benefits of dietary on the modulation of gut microbiome composition, along with differences between sexes.
乳香，通常被称为乳香，几个世纪以来一直被用作天然的抗炎和抗菌药物，用于治疗许多疾病。然而，其生物活性成分 3-O-乙酰-11-酮-β-乳香酸（AKBA）对肠道微生物组和血液代谢物的影响尚不清楚。在这项研究中，我们观察了这种分离的活性成分对雄性和雌性小鼠口服的影响。在 14 天的消耗期开始和结束时，分别测定肠道微生物群和血液代谢物。AKBA 显著降低了雄性小鼠肠道细菌的丰富度，但对雌性小鼠没有影响。与体重减轻和抗炎相关的，在雄性和雌性小鼠中均显著增加，同时雌性小鼠中的 增加。将 和 分别接种在含有不同浓度 AKBA（0%、0.001%、0.01%和 0.1%）的培养基上。AKBA 的所有浓度均完全抑制了 的生长，但对 没有影响。雄性和雌性之间有几种血液代谢物因 AKBA 而不同。这些结果表明，饮食中的乳香可能对肠道微生物组组成的调节有潜在益处，同时也存在性别差异。
