Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
Clinic for Visceral, Transplantation and Thorax and Vascular Surgery, University Hospital Leipzig, 04103 Leipzig, Germany.
Int J Mol Sci. 2022 Feb 17;23(4):2222. doi: 10.3390/ijms23042222.
(1) Adipsin is an adipokine that may link increased fat mass and adipose tissue dysfunction to obesity-related cardiometabolic diseases. Here, we investigated whether adipsin serum concentrations and adipose tissue (AT) mRNA expression are related to parameters of AT function, obesity and type 2 diabetes (T2D). (2) Methods: A cohort of 637 individuals with a wide range of age and body weight (Age: 18-85 years; BMI: 19-70 kg/m) with (n = 237) or without (n = 400) T2D was analyzed for serum adipsin concentrations by ELISA and visceral (VAT) and subcutaneous (SAT) mRNA expression by RT-PCR. (3) Results: Adipsin serum concentrations were significantly higher in patients with T2D compared to normoglycemic individuals. We found significant positive univariate relationships of adipsin serum concentrations with age (r = 0.282, < 0.001), body weight (r = 0.264, < 0.001), fasting plasma glucose (r = 0.136, = 0.006) and leptin serum concentrations (r = 0.362, < 0.001). Neither VAT nor SAT mRNA expression correlated with adipsin serum concentrations after adjusting for age, sex and BMI. Independent of T2D status, we found significantly higher expression in SAT compared to VAT (4) Conclusions: Our data suggest that adipsin serum concentrations are strongly related to obesity and age. However, neither circulating adipsin nor AT expression reflects parameters of impaired glucose or lipid metabolism in patients with obesity with or without T2D.
(1) 脂联素是一种脂肪因子，它可能将脂肪质量增加和脂肪组织功能障碍与肥胖相关的代谢性心血管疾病联系起来。在这里，我们研究了脂联素血清浓度和脂肪组织 (AT) mRNA 表达是否与 AT 功能、肥胖和 2 型糖尿病 (T2D) 的参数有关。
(2) 方法：分析了一组年龄和体重范围广泛的 637 名个体（年龄：18-85 岁；BMI：19-70 kg/m），其中 237 名患有 T2D，400 名无 T2D，通过 ELISA 测定血清脂联素浓度，通过 RT-PCR 测定内脏 (VAT) 和皮下 (SAT) mRNA 表达。
(3) 结果：与血糖正常的个体相比，T2D 患者的血清脂联素浓度显著升高。我们发现血清脂联素浓度与年龄（r = 0.282， < 0.001）、体重（r = 0.264， < 0.001）、空腹血浆葡萄糖（r = 0.136， = 0.006）和瘦素血清浓度（r = 0.362， < 0.001）呈显著正相关。调整年龄、性别和 BMI 后，VAT 和 SAT 的 mRNA 表达均与脂联素血清浓度无关。独立于 T2D 状态，我们发现 SAT 的表达显著高于 VAT（4）结论：我们的数据表明，脂联素血清浓度与肥胖和年龄密切相关。然而，无论是循环脂联素还是 AT 表达，都不能反映肥胖患者伴或不伴 T2D 的糖或脂质代谢受损的参数。
