Hernández-Díaz Yazmín, de Los Ángeles Ovando-Almeida María, Fresán Ana, Juárez-Rojop Isela Esther, Genis-Mendoza Alma Delia, Nicolini Humberto, González-Castro Thelma Beatriz, Tovilla-Zárate Carlos Alfonso, López-Narváez María Lilia
División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez 86205, Tabasco, Mexico.
Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México 14370, Mexico.
Int J Mol Sci. 2024 Nov 26;25(23):12668. doi: 10.3390/ijms252312668.
A large number of studies have reported the relationships between leptin levels and diabetes or obesity. However, the results are still controversial, and no consensus has been reached. Therefore, the purpose of the study was to collect data from various databases to perform a meta-analysis and address the inconsistencies in these studies. A systematic literature search was conducted on PubMed, Web of Science, and EBSCO for relevant available articles. The pooled standard mean difference (SMD) with 95% confidence interval (CI) was used to estimate the association by a meta-analysis. Fifteen reports with 1,388 cases and 3,536 controls were chosen for the meta-analysis. First, an increase in leptin levels in serum (SMD 0.69; 95% CI 0.36-1.02 ng/mL) and plasma (SMD 0.46; 95% CI 0.18-0.74 ng/mL) was observed in individuals with diabetes compared to controls. This increased level was also observed by gender and population. Second, statistical analysis showed that leptin levels in serum were significantly increased in individuals with obesity (SMD 1.03; 95% CI 0.72-1.34 ng/mL). This meta-analysis analyzed leptin in individuals with diabetes or obesity and emphasized the importance of monitoring serum/plasma leptin levels in patients with these diseases. However, more comprehensive studies are necessary in order to draw firm conclusions.
大量研究报告了瘦素水平与糖尿病或肥胖症之间的关系。然而，结果仍存在争议，尚未达成共识。因此，本研究的目的是从各种数据库收集数据，进行荟萃分析，并解决这些研究中的不一致之处。我们在PubMed、Web of Science和EBSCO上进行了系统的文献检索，以查找相关的可用文章。通过荟萃分析，使用合并标准均数差（SMD）及95%置信区间（CI）来估计关联性。我们选择了15篇报告，共1388例病例和3536例对照进行荟萃分析。首先，与对照组相比，糖尿病患者血清（SMD 0.69；95% CI 0.36 - 1.02 ng/mL）和血浆（SMD 0.46；95% CI 0.18 - 0.74 ng/mL）中的瘦素水平升高。按性别和人群分析也观察到了这种升高。其次，统计分析表明，肥胖个体血清中的瘦素水平显著升高（SMD 1.03；95% CI 0.72 - 1.34 ng/mL）。这项荟萃分析分析了糖尿病或肥胖个体中的瘦素，并强调了监测这些疾病患者血清/血浆瘦素水平的重要性。然而，为了得出确凿的结论，还需要进行更全面的研究。
