Vowden P, Lowe A D, Lennox E S, Bleehen N M
Br J Cancer. 1986 Jun;53(6):721-5. doi: 10.1038/bjc.1986.124.
An interesting and not previously reported parallel has been observed between the known pattern of ABO (H) blood group isoantigen expression in normal and neoplastic colonic epithelium and that in the thyroid. Epithelial expression of blood group isoantigens was not observed in 16 specimens of normal or non-neoplastic thyroid tissue. This contrasts with the progressive re-expression of these antigens in neoplastic thyroid tissue. Blood group isoantigens were detected in two of eight papillary adenomas and 13 of 17 papillary carcinomas. Antigen expression was in part related to differentiation, and stained cells were less readily detected in follicular tumours, only one of five adenomas and two of seven carcinomas displaying blood group antigens while three medullary and two anaplastic carcinomas were antigen-deficient.
在正常和肿瘤性结肠上皮以及甲状腺中已知的ABO（H）血型同种抗原表达模式之间，观察到了一种有趣且此前未报道过的相似之处。在16份正常或非肿瘤性甲状腺组织标本中未观察到血型同种抗原的上皮表达。这与这些抗原在肿瘤性甲状腺组织中的逐渐重新表达形成对比。在8例乳头状腺瘤中有2例以及17例乳头状癌中有13例检测到血型同种抗原。抗原表达部分与分化有关，在滤泡性肿瘤中较难检测到染色细胞，5例腺瘤中只有1例、7例癌中只有2例显示出血型抗原，而3例髓样癌和2例未分化癌缺乏抗原。
