Larena A, Vierbuchen M, Fischer R
Department of Surgery, General Hospital Harburg, Germany.
Langenbecks Arch Chir. 1995;380(5):269-72. doi: 10.1007/BF00184101.
Blood group antigen (BGA) expression has been described in many fetal, adult, and tumorous tissues. Synthesis of BGA in the thyroid gland is regarded as oncofetal due to blood group structures that are detected in fetal and carcinomatous tissues but not in the normal adult organ. This study examined the prevalence of type 1 (CA-50, CA-19-9, Lea, Leb, A, B, H type 1) and type 2 (Le(x), Le(y), A, B, H type 2) antigens in normal thyroid (n = 25), papillary (n = 104), follicular (n = 52), anaplastic (n = 33), and medullary (n = 48) carcinomas of the thyroid. While normal thyroid tissue expressed no BGA, there was a significant increase of BGA expression in carcinomas of the thyroid gland. There are two theories about the possible origin of C cells, from which the medullary carcinomas arise. Some authors postulate that C cells belong to the amine precursor uptake and decarboxylation system and therefore derive from the neural crest, while others believe that C cells originate from the fifth pharyngeal pouch, as do the follicular cells. The results obtained in this study show that medullary and nonmedullary carcinomas correspond to one another in their BGA expression profile. Therefore it is concluded that medullary carcinomas may have the same origin as nonmedullary tumors of the thyroid.
血型抗原（BGA）表达已在许多胎儿、成人及肿瘤组织中被描述。由于在胎儿和癌组织中可检测到血型结构，而在正常成人器官中未检测到，甲状腺中BGA的合成被视为癌胚性的。本研究检测了正常甲状腺组织（n = 25）、乳头状癌（n = 104）、滤泡状癌（n = 52）、未分化癌（n = 33）和髓样癌（n = 48）中1型（CA - 50、CA - 19 - 9、Lea、Leb、A、B、H 1型）和2型（Le(x)、Le(y)、A、B、H 2型）抗原的发生率。正常甲状腺组织不表达BGA，而甲状腺癌中BGA表达显著增加。关于髓样癌起源的C细胞的可能来源有两种理论。一些作者推测C细胞属于胺前体摄取和脱羧系统，因此起源于神经嵴，而另一些人认为C细胞与滤泡细胞一样起源于第五鳃囊。本研究获得的结果表明，髓样癌和非髓样癌在其BGA表达谱上相互对应。因此得出结论，髓样癌可能与甲状腺非髓样肿瘤有相同的起源。
