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一项针对精神分裂症社会功能结局测量的系统评价,重点关注干预研究的适用性。

A systematic review of social functioning outcome measures in schizophrenia with a focus on suitability for intervention research.

机构信息

Division of Psychiatry, University College London, United Kingdom of Great Britain and Northern Ireland; Research and Development, North East London NHS Foundation Trust, United Kingdom of Great Britain and Northern Ireland.

Division of Psychiatry, University College London, United Kingdom of Great Britain and Northern Ireland; Research and Development, North East London NHS Foundation Trust, United Kingdom of Great Britain and Northern Ireland.

出版信息

Schizophr Res. 2022 Mar;241:275-291. doi: 10.1016/j.schres.2022.02.011. Epub 2022 Feb 22.

Abstract

Social functioning is an important part of recovery and a key treatment target in clinical research in schizophrenia. Evaluating and comparing interventions is challenged by the choice of many measures which focus on different aspects of functioning, with little to guide selection. This results in difficulties comparing outcomes of treatment where studies have used different measures. To improve the measurement of social functioning in intervention research, we aimed to provide practical information on suitability of measures. We conducted a systematic review of measures developed or psychometrically evaluated since 2007, and assessed and discussed the structure, content, quality, and the use of the measures in intervention research. Thirty-two measures of social functioning and 22 validation papers were identified. Measures included structured questionnaires, semi-structured interviews, and assessment of performance on specific tasks. The content of measures was organised into eight categories, which are in order of frequency with which they were covered by measures: activities of daily living, productive activity, relationships, leisure activities, cognition, anti-social behaviour, psychosis symptoms and self-esteem and empowerment. In terms of quality, most measures were rated as moderate, with the Personal and Social Performance Scale gaining the highest rating. However, there was little data on responsiveness of measures, or how they compare to objective or 'real-world' indicators of functioning. The Social Functioning Scale and Personal and Social Performance Scale have been most frequently used in intervention studies to date. Future research should aim to provide further data on psychometric properties relevant to intervention research.

摘要

社会功能是康复的重要组成部分,也是精神分裂症临床研究中的关键治疗目标。评估和比较干预措施的选择受到许多措施的挑战,这些措施侧重于功能的不同方面,几乎没有指导选择。这导致在使用不同措施的研究中比较治疗结果时出现困难。为了改善干预研究中社会功能的测量,我们旨在提供有关措施适用性的实用信息。我们对 2007 年以来开发或心理测量评估的措施进行了系统评价,并评估和讨论了措施的结构、内容、质量以及在干预研究中的使用。确定了 32 种社会功能措施和 22 份验证文件。措施包括结构化问卷、半结构化访谈以及对特定任务表现的评估。措施的内容分为八个类别,按其涵盖的频率排列:日常生活活动、生产性活动、人际关系、休闲活动、认知、反社会行为、精神病症状以及自尊和赋权。就质量而言,大多数措施被评为中等,个人和社会表现量表获得的评分最高。然而,关于措施的反应性或它们与功能的客观或“现实世界”指标的比较的数据很少。迄今为止,社会功能量表和个人和社会表现量表在干预研究中使用最频繁。未来的研究应旨在提供与干预研究相关的心理测量特性的进一步数据。

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