Jasemi Sayed Vahid, Khazaei Hosna, Momtaz Saeideh, Farzaei Mohammad Hosein, Echeverría Javier
Department of Internal Medicine, Faculty of Medicine, Kermanshah University of Medical Sciences, Iran.
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Science, Kermanshah, Iran.
Phytomedicine. 2022 May;99:153988. doi: 10.1016/j.phymed.2022.153988. Epub 2022 Feb 17.
Chronic obstructive pulmonary disease (COPD) is a class of lung diseases including chronic bronchitis, asthma, and emphysema. Long-time smoking is considered the main reason for developing emphysema. Emphysema can be defined as damage to the walls of the air sacs (alveoli) of the lung. It has been demonstrated that natural compounds with antioxidant and anti-inflammatory effects can effectively improve or protect the lung against this disease. This paper is dedicated to systematically review the effective natural compounds in the treatment of pulmonary emphysema.
This is the first systematic and comprehensive review on the role of plant-derived secondary metabolites in managing and/or treating pulmonary emphysema STUDY DESIGN AND METHODS: A systematic and comprehensive review was done based on Scopus, PubMed, and Cochrane Library databases were searched using the "emphysema", "plant", "herb", and "phytochemical" keywords. Non-English, review, and repetitive articles were excluded from the study. Search results were included in the Prisma diagram.
From a total of 1285 results, finally, 22 articles were included in the present study. The results show that some herbs such as Scutellaria baicalensis Georgi and Monascus adlay and some phytochemicals such as gallic acid and quercetin and blackboard tree indole alkaloids affect more factors in improving the lung emphysema. Also, some natural compounds such as marijuana smoke and humic acid also play an aggravating role in this disease. It also seems that some of the medicinal plants such as PM014 herbal formula, pomegranate juice and açaí berry sometimes have side effects that are inconsistent with their therapeutic effects.
We concluded that natural compounds can effectively improve pulmonary emphysema due to their antioxidant, anti-inflammatory, and anti-apoptotic properties. However, additional studies are suggested to prove efficacy and side effects.
慢性阻塞性肺疾病（COPD）是一类肺部疾病，包括慢性支气管炎、哮喘和肺气肿。长期吸烟被认为是患肺气肿的主要原因。肺气肿可定义为肺部气囊（肺泡）壁的损伤。已经证明，具有抗氧化和抗炎作用的天然化合物可以有效改善或保护肺部免受这种疾病的侵害。本文致力于系统综述治疗肺气肿的有效天然化合物。
这是第一篇关于植物源次生代谢产物在管理和/或治疗肺气肿中作用的系统全面综述。
基于Scopus、PubMed和Cochrane图书馆数据库进行系统全面综述，使用“肺气肿”“植物”“草药”和“植物化学物质”等关键词进行搜索。非英文、综述和重复的文章被排除在研究之外。搜索结果纳入Prisma图表。
从总共1285个结果中，最终本研究纳入了22篇文章。结果表明，一些草药如黄芩和红曲以及一些植物化学物质如没食子酸、槲皮素和黑板树吲哚生物碱在改善肺气肿方面影响更多因素。此外，一些天然化合物如大麻烟雾和腐殖酸在这种疾病中也起加重作用。似乎一些药用植物如PM014草药配方、石榴汁和阿萨伊浆果有时会有与其治疗效果不一致的副作用。
我们得出结论，天然化合物因其抗氧化、抗炎和抗凋亡特性可有效改善肺气肿。然而，建议进行更多研究以证明其疗效和副作用。
