Alberts Adina, Moldoveanu Elena-Theodora, Niculescu Adelina-Gabriela, Grumezescu Alexandru Mihai
Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania.
Int J Mol Sci. 2024 Dec 14;25(24):13410. doi: 10.3390/ijms252413410.
(NS) is an annual herb belonging to the Ranunculaceae family, also known as black cumin or black seed. This plant has been used since ancient times due to its therapeutic properties and has proven effective in gastrointestinal, respiratory, cardiovascular, infectious, and inflammatory conditions. In this review, the aim is to highlight the therapeutic effects of the plant known in Arab countries as "the plant that cures any disease", which are provided by the phytochemical compounds in its composition, such as thymoquinone, p-cymene, α-thujene, longifolene, β-pinene, α-pinene, and carvacrol. These compounds confer an antioxidant effect to the seeds, leading to a significant decrease in ROS and a potent anti-inflammatory effect. Also, in this review, the aim is to highlight that NS seeds may have a synergistic effect with other drugs, such as chemotherapeutic agents or antibiotics, which may lead to a reduction in the therapeutic dose, may have an improved effect, and could lead to overcoming obstacles such as drug resistance. The studies provided in this review showed that NS has the potential to be a therapeutic agent both as a monotherapy and as an adjuvant. Although there are studies demonstrating the therapeutic properties of NS, there is a need for much more extensive research and more clinical trials with clearly established objectives so that the mechanism of action of the active substances in NS is much better understood. With the data provided so far, NS can be used in food and drug production in small quantities and can be administered for short periods. Further investigations may lead to an understanding of the therapeutic profile and the most effective mode of administration, as well as a clearer perspective on the toxicological profile of NS.
黑种草（NS）是一种属于毛茛科的一年生草本植物，也被称为黑孜然或黑籽。由于其治疗特性，这种植物自古以来就被使用，并且已被证明对胃肠道、呼吸道、心血管、感染性和炎症性疾病有效。在这篇综述中，目的是强调在阿拉伯国家被称为“能治愈任何疾病的植物”的这种植物的治疗效果，这些效果由其成分中的植物化学化合物提供，如百里醌、对异丙基甲苯、α-侧柏烯、长叶烯、β-蒎烯、α-蒎烯和香芹酚。这些化合物赋予种子抗氧化作用，导致活性氧显著减少，并具有强大的抗炎作用。此外，在这篇综述中，目的是强调黑种草种子可能与其他药物，如化疗药物或抗生素，产生协同作用，这可能导致治疗剂量减少、效果改善，并可能克服诸如耐药性等障碍。这篇综述中提供的研究表明，黑种草作为单一疗法和辅助疗法都有成为治疗剂的潜力。尽管有研究证明了黑种草的治疗特性，但仍需要更广泛的研究和更多目标明确的临床试验，以便更好地理解黑种草中活性物质的作用机制。根据目前提供的数据，黑种草可以少量用于食品和药物生产，并且可以短期给药。进一步的研究可能会导致对其治疗概况和最有效的给药方式的理解，以及对黑种草毒理学概况更清晰的认识。
