Bajoghli Amir A, Piselli Alexandra, Kemprecos Helen, Khosravi Hamed, Cardis Michael A, Noel Marcus S
Skin and Laser Surgery Center, PC 1359 Beverly Rd 2nd Floor, McLean, VA 22101 United States.
Lombardi Comprehensive Cancer Center, Medstar Georgetown University Hospital 3800 Reservoir Rd NW, Washington, DC 20007 United States.
Cancer Treat Res Commun. 2022;31:100532. doi: 10.1016/j.ctarc.2022.100532. Epub 2022 Feb 12.
Cutaneous metastasis resulting from internal primary tumors remains a rare phenomenon. The prompt recognition of these metastases is important, as they are an indicator of advanced disease and poor prognosis. We report the case of a 44-year-old Caucasian man presenting with a four-month history of multiple cutaneous nodules on the face, trunk, and upper extremities. Results from skin biopsy revealed strands and cords of atypical cells concerning for poorly differentiated metastatic carcinoma. An esophagogastroduodenoscopy was performed and a poorly differentiated signet-ring type invasive adenocarcinoma at the lesser curvature of the stomach was found. As the cancer had already metastasized to the skin and bones, the patient was started on chemotherapy with an oxaliplatin-based regimen and denosumab for the bone metastases, with resultant objective response and diagnostic control for greater than one year to the present date.
由体内原发性肿瘤引起的皮肤转移仍然是一种罕见现象。及时识别这些转移瘤很重要，因为它们是疾病晚期和预后不良的指标。我们报告了一例44岁的白种男性患者，其面部、躯干和上肢出现多个皮肤结节已有四个月病史。皮肤活检结果显示有非典型细胞条索和索状结构，提示为低分化转移性癌。进行了食管胃十二指肠镜检查，发现胃小弯处有低分化印戒型浸润性腺癌。由于癌症已转移至皮肤和骨骼，患者开始接受以奥沙利铂为基础的化疗方案以及针对骨转移的地诺单抗治疗，目前已获得客观缓解并实现诊断性控制超过一年。
