Division of Psychology and Mental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK.
Clin Psychol Psychother. 2022 Sep;29(5):1692-1706. doi: 10.1002/cpp.2731. Epub 2022 Apr 6.
Negative symptoms have an adverse impact on quality of life and functioning in psychosis. Service users with psychosis have identified negative symptoms as a priority for their recovery. Despite this, there is a lack of effective and targeted psychological interventions for negative symptoms and their underlying mechanisms remain poorly understood. Childhood trauma is a robust risk factor for positive symptoms in psychosis, but the association with negative symptoms is less well established. Our aim was to examine the association between childhood interpersonal trauma and negative symptoms and the psychological mediators of this relationship. Two hundred and forty participants experiencing psychosis completed validated self-report measures of childhood trauma, attachment, dissociation, compartmentalization, and symptoms. Mediation analyses showed that disorganized attachment and dissociative experiences mediated the association between childhood trauma and negative symptoms, when analysed individually and in a combined model. Models adjusted for age and positive and depressive symptoms. Avoidant attachment and compartmentalization were independently associated with negative symptoms but not childhood trauma and thus were not significant mediators. Childhood trauma was not independently associated with negative symptoms. This paper is the first to present empirical data to support a model implicating attachment and dissociation as important psychological processes in the link between childhood trauma and negative symptoms. These exploratory findings suggest that it may be beneficial to consider these relationships in trauma-informed formulations and interventions. Further longitudinal research is required to establish causality and test theoretical models of mechanisms in the pathway to negative symptoms.
阴性症状对精神病患者的生活质量和功能有不良影响。患有精神病的服务使用者将阴性症状确定为康复的优先事项。尽管如此,针对阴性症状的有效且针对性的心理干预措施仍然缺乏,其潜在机制也知之甚少。儿童期创伤是精神病阳性症状的一个强有力的风险因素,但与阴性症状的关联尚未得到充分证实。我们的目的是研究儿童期人际创伤与阴性症状之间的关系,以及这种关系的心理中介因素。240 名经历精神病的参与者完成了儿童期创伤、依恋、分离、分隔和症状的验证性自我报告测量。中介分析表明,当单独分析和在综合模型中分析时,组织不良的依恋和分离体验介导了儿童期创伤与阴性症状之间的关联。对年龄、阳性和抑郁症状进行了调整的模型。回避型依恋和分隔与阴性症状独立相关,但与儿童期创伤无关,因此不是重要的中介因素。儿童期创伤与阴性症状没有独立的关联。本文首次提出了实证数据,支持这样一种模式,即依恋和分离是儿童期创伤与阴性症状之间联系的重要心理过程。这些探索性发现表明,在创伤知情的发病机制和干预措施中考虑这些关系可能是有益的。需要进一步的纵向研究来确定因果关系,并测试阴性症状发生途径中的机制理论模型。