Schleusser Sophie, Schulz Lysann, Song Jungin, Deichmann Henriette, Griesmann Anna-Catharina, Stang Felix H, Mailaender Peter, Kraemer Robert, Kleemann Markus, Kisch Tobias
Department of Plastic Surgery, Hand Surgery and Burn Care Unit, University Hospital Schleswig-Holstein, Lübeck, Germany.
Department of Interdisciplinary Intensive Care, University Hospital Leipzig, Leipzig, Germany.
Microcirculation. 2022 Apr;29(3):e12754. doi: 10.1111/micc.12754. Epub 2022 Mar 7.
To find out whether application of cold atmospheric plasma (CAP) affects microcirculation in chronic wounds.
We treated 20 patients with chronic wounds on the lower extremity with CAP. Blood flow parameters of wounds were assessed with combined Laser-Doppler-Flowmetry and spectrophotometry in tissue depth of 2 and 6-8 mm. Parameters were assessed under standardized conditions before and over the course of 30 min after application of CAP.
Deep capillary blood flow increased significantly by up to 24.33% (percentage change) after treatment with CAP and remained significantly elevated until the end of measuring period at 30 min. Superficial oxygen tissue saturation was significantly elevated by 14.05% for the first 5 min after treatment. Postcapillary venous filling pressure was significantly elevated by 10.23% 19 min after CAP and stayed significantly elevated starting from minute 24 until the end of measuring.
Cold atmospheric plasma increases microcirculation parameters in chronic wounds significantly. As CAP is known for its benefits in wound healing, the effects observed may explain the improved healing of chronic wounds after its use. Whether CAP-application can increase blood flow in chronic wounds for longer periods of time or boosts blood flow when applied more than once should be subject to further research.
探究冷大气等离子体（CAP）的应用是否会影响慢性伤口的微循环。
我们用CAP治疗了20例下肢慢性伤口患者。采用激光多普勒血流仪和分光光度法联合评估伤口在2毫米和6 - 8毫米组织深度处的血流参数。在CAP应用前的标准化条件下以及应用后30分钟内评估这些参数。
用CAP治疗后，深部毛细血管血流量显著增加，最高可达24.33%（百分比变化），并且在测量期30分钟结束前一直保持显著升高。治疗后的前5分钟，浅表组织氧饱和度显著升高14.05%。CAP应用19分钟后，毛细血管后静脉充盈压显著升高10.23%，从第24分钟开始一直保持显著升高直至测量结束。
冷大气等离子体显著增加慢性伤口的微循环参数。由于CAP在伤口愈合方面的益处是已知的，观察到的这些效应可能解释了其使用后慢性伤口愈合得到改善的原因。CAP应用是否能在更长时间内增加慢性伤口的血流量，或者多次应用时是否能促进血流，有待进一步研究。
